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Chapter 14 Hallucinogenic Drugs. Mescaline Peyote cactus. Psilocybin Psilocybe mushrooms psilocybin  psilocin. LSD . Pharmacology of Hallucinogenic Drugs . Pharmacology of Hallucinogenic Drugs . LSD Trip (psychological effects) Onset Plateau Peak Come-down.

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slide6

Pharmacology of Hallucinogenic Drugs

LSD Trip (psychological effects)

  • Onset
  • Plateau
  • Peak
  • Come-down
slide7

Pharmacology of Hallucinogenic Drugs

Physiological effects

  • Activate sympathetic nervous system
    • Dilated pupils
    • Heart rate increase
    • Blood pressure increase
    • Body temperature increase
  • Dizziness
  • Nausea and vomiting
slide8

Pharmacology of Hallucinogenic Drugs

Most hallucinogens are 5-HT receptor agonists

If you use a 5-HT receptor antagonists together with a hallunicongen, illusions and hallucinations disappear

slide9

Pharmacology of Hallucinogenic Drugs Acquisition of an LSD/saline discrimination and attenuation of the drug stimulus cue

slide10

Pharmacology of Hallucinogenic Drugs Acquisition of an LSD/saline discrimination and attenuation of the drug stimulus cue

slide11

http://www.antidrug.health.am/img/haluc.jpg

Pharmacology of Hallucinogenic Drugs

Problems with hallucinogenic drugs

  • “Bad Trip”
  • Flashbacks
  • Psychotic breakdown
slide13

Dissociative Anesthetics

Ketamine crystals