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Telomerase Expression and Telomeric Stabilisation. Telomeres. Protective caps . Prevent chromosomal fusion. Short 5-8 bp tandem repeated G rich segments (TTAGGG). L ength decreases with progressive rounds of cell replication, concluding in cell senescence. Telomerase.

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Telomerase Expression and Telomeric Stabilisation


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telomeres
Telomeres
  • Protective caps .
  • Prevent chromosomal fusion.
  • Short 5-8 bp tandem repeated G rich segments (TTAGGG).
  • Length decreases with progressive rounds of cell replication, concluding in cell senescence.
telomerase
Telomerase
  • Maintains telomere length.
  • Dictates synthesis of telomeric repeats onto DNA substrates.
  • Telomerase expression increases with grade of CIN.
    • Active form of telomerase is hTERT.
    • Full length RNA is called hTR.
  • Quantitative differences in expresion of hTR telomerase in normal, CIN and invasive phenotypes.