Toxicokinetics 1. Crispin Pierce, Ph.D. University of Washington firstname.lastname@example.org (206) 616-4390. Absorption.
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Crispin Pierce, Ph.D.
University of Washington
Absorption assumes primary importance in oral, inhalation, and dermal exposures. The two kinetic parameters of concern are the rate of absorption and the extent of absorption (or bioavailability).
- prolonged Tp
- lower Cmax
In instances when the absorption rate is slower than elimination rate, the rate of washout of toxicant becomes rate-limited by absorption rather than by elimination (i.e., a depot effect).
CL = F·Dose/AUC