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All that Maths and Frontier in Biostatistics

All that Maths and Frontier in Biostatistics. David Bin Shiun Wu 吳秉勳 , PhD Candidate Division of Biostatistics, Graduate Institute of Public Health, National Yang Ming University, Taipei, Taiwan March 4, 2009. My Biography. Bachelors in mathematics and English ( 雙主修 ), 東吳大學

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All that Maths and Frontier in Biostatistics

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  1. All that Maths and Frontier in Biostatistics David Bin Shiun Wu 吳秉勳, PhD Candidate Division of Biostatistics, Graduate Institute of Public Health, National Yang Ming University, Taipei, Taiwan March 4, 2009

  2. My Biography • Bachelors in mathematics and English (雙主修), 東吳大學 • Master in statistics, 政治大學 統計研究所 • PhD candidate in biostatistics,陽明大學 醫學院 公共衛生研究所 生物統計組 • Statistical consultant, 統計諮詢師 林口長庚醫院 臨床研究統計中心

  3. Resource Center for Clinical Research (RCCR) About Me

  4. 中華民國管理科學會30周年慶 首場系列經濟發展座談會 l 田蔚城（明生生物科技董事長）: – 人生的目的不外乎 l 生得好， l 老得慢， l 病得輕， l 死得安。 • 生技產業在生、老、病、死都可以幫上忙， 協助實現人生目的。

  5. What Do Biostatisticians Do inBiomedical Research?

  6. Biomedical Research 生物醫學研究 Basic Science Research 基礎醫學研究 Lab Studies, Animal Studies Clinical Medicine Research 臨床醫學研究 Disease Studies, Experimental Studies, Interventional Studies Clinical Trials Studies臨床試驗研究 Drug Studies, Phase I, II, III, IV Other Related Studies Public Health, Health Psychology,Behavior Science, Health Economics, Bioethics, etc.

  7. 國立陽明大學 公共衛生研究所 Institute of Public Health,NationalYang-MingUniversity 98 年 度 碩士甄試招生訊息 ※招生規定及內容以本校招生簡章為準 ：http://www.ym.edu.tw/adm/ 公衛所網站：http://sm.ym.edu.tw/index/ 專 任 教 師 姓名 學位 專長 周碧瑟 杜蘭大學公共衛生博士 流行病學、社區醫學、預防醫學、身心健康促進 陳震寰 國立陽明大學醫學院醫學系 心臟超音波、血流動力學、心臟血管流行病學 黃嵩立 哈佛大學環境衛生博士 國際衛生、空氣污染與肺部疾病 周穎政 哈佛大學衛生政策博士 衛生政策、醫療經濟 傅瓊瑤 南卡羅萊納大學生物統計學博士 生物醫學及公衛領域的應用統計 楊秀儀 史丹福大學法學博士 醫療法律、生命倫理 雷文玫 耶魯大學法學博士 生殖科技法律與倫理、基因醫療法律與倫理 林明薇 倫敦大學精神醫學研究所精神遺傳學博士 遺傳流行病學、精神遺傳學、生物統計學 林逸芬 哥倫比亞大學公共衛生(生物統計)博士 流行病學統計方法、長期追蹤資料分析 邱淑媞 臺灣大學流行病學博士 預防醫學、慢性病防治、衛生政策 姓名 學位 專長 陳宜民 哈佛大學公共衛生博士　　　　　　　　　 　 癌生物學、病毒學、分子流行病學 王錦鈿 奧瑞岡醫學中心微生物及免疫學博士 愛滋病病毒學 范盛娟 愛荷華大學生物統計學博士 遺傳統計、遺傳流行病學 黃景祥 哈佛大學統計學博士 貝氏統計推論、環境統計 簡莉盈 約翰霍普金斯大學公共衛生(心理衛生)博士 婦幼衛生、 健康促進 鄧宗業 哈佛公共衛生學院衛生政策博士 衛生政策制定、醫療專業 黃心苑 約翰霍普金斯大學衛生政策博士 衛生政策、醫療品質 詹宇鈞 約翰霍浦金斯大學醫學院藥理及分子醫學博士 內科學、分子生物學、分子病毒學、感染症 季麟揚 劍橋大學社區醫學博士 生活品質研究、口腔健康促進、衛生計畫評價 楊振昌 哈佛大學公共衛生學院公共衛生(流行病學)博士 藥物流行病學、臨床毒物學、環境暨職業醫學 郭文華 麻省理工學院科技與社會博士 東亞醫學史、醫療與社會 教 師 專 合 聘 教 師 長

  8. What is BioStatistics? Statistics Applied to Biomedical Data Method Technique Science Strategy

  9. What is BioStatistics? Mathematics others Medicine Basic Clinical Biostatistics Statistics Collaborative Science

  10. inference inference Truth in the Universe Truth in the Study Findings in the Study Physiology of Research Investigator’s View: Internal Validity 內部效度 External Validity 外部效度 Hulley & Cummings: Designing Clinical Research

  11. Collaborating Team Work Principal Investigator Biostatistician Lab Scientist Research Nurse Data Programmer etc.

  12. Randomized Clinical Trial (RCT) 隨機化臨床試驗 Preparation of initial clinical plan. Selection of clinical study locations PHASE I Human trials with healthy volunteers to test tolerability PHASE II Trials to determine dose ranging, safety and efficacy PHASE III Large scale trials to determine definitive safety and efficacy in patients Research and Discovery Early Development Full Development Pre-Market Activity 0 5 8 12 15 Years

  13. EFFECTIVENESS效果 “Outcomes結果” studies EFFICACY療效 RCTs Can you assume that RCT results will be reflected in actual practice?

  14. Effectiveness (效果) Efficacy Effectiveness Efficiency Does it contribute to a more efficient use of resources? Does it work in real life? Can it work in clinical practice? (proven in RCTs  ideal conditions)

  15. PharmacoEconomics(PE)藥物經濟學 “A comparative analysis of alternative courses of action in terms of both their costs and effectiveness. ” Drummond et al., Oxford University Press, 1987:8.

  16. The 4th Hurdle(門檻): PharmacoEconomics Quality Safety Efficacy Pharmacoeconomics (PE) Wait S. Cambridge University Seminars, 2002

  17. Cost-Effectiveness Ratio Societal Perspective (社會觀點) Hospital costs Physician costs Lab costs Medical costs Indirect (Opportunity) costs Payer’s Perspective (健保給付者觀點) Hospital costs Physician costs Lab costs Medical costs Life-year Gained

  18. CUA ratio denominator Healthy Quality-adjusted Life Year (QaLY) Gained Morbidity Mortality

  19. Humanistic (“Intangible”) Outcomes "Not everything that counts can be counted, and not everything that can be counted counts."

  20. Some Projects I’ve Worked(-ing) On • 美商惠氏藥廠 產學合作計畫 • ISPOR 3rd Asia-Pacific Conference, Seoul, South Korea, 7-9 September, 2008 七價肺炎鏈球菌疫苗 (PCV7)

  21. Some Projects I’ve Worked(-ing) On • Decision analytic model

  22. Some Projects I’ve Worked(-ing) On • Incremental Cost-Effectiveness Ratio (ICER) • Or termed as Cost per Life-Year Gained (CLYG) ICER=ΔC /ΔE = Costvac – Costunvac / Effectivenessvac – Effectivenessunvac Incremental costs by the vaccination Incremental life years gained by the vaccination

  23. Some Projects I’ve Worked(-ing) On

  24. Some Projects I’ve Worked(-ing) On • 國科會計畫 (三年期) • ISPOR 11th Annual European Congress, Athens, Greece, 8-11 November, 2008

  25. Some Projects I’ve Worked(-ing) On • When “Math” meets “Biostatsitics” !

  26. Herd Effect (集群免疫) Example of Epidemic with No herd effect

  27. Herd Effect (集群免疫) Example of Epidemic with herd effect

  28. Some Projects I’ve Worked(-ing) On • ISPOR 14th Annual International Meeting, Orlando, FL, 16-20 May, 2009 • Optimization of vaccination strategy with limited doses

  29. Some Projects I’ve Worked(-ing) On • Grant by Center for Disease Control (CDC, 行政院疾病管制局) • Cost-effectiveness of PPV23 (PPV23, 23價肺炎鏈球菌疫苗 )

  30. What are your advantages?

  31. Your Advantages 優勢 ….As a mathematics-major student…. • 邏輯分析訓練 • 學科的整合運用 • 思考路徑訓練，有助於化繁為簡

  32. Some Advices • 將抽象的概念具體化 (Picture) • 多聽Seminar(聽不懂沒關係) • 培養直覺的觀點(尋找有趣的例子) - 好的題目需要好的眼光(感性) - 好的研究能力是理性(大學四年基礎) • 小組討論

  33. How to Become a (Bio) statistician? It’s a long road... • Bachelors Degree (B.S.) in Mathematics • Or other mathematics-intense discipline like engineering, economics, physics, etc. • Rigid logic training • Masters Degree (M.S.) in Statistics/Biostatistics • 2+ years beyond B.S. • Work involves mostly programming under the direction of a Ph.D.-level statistician; not too exciting; but money is good! • Doctoral Degree (Ph.D.) in Statistics/Biostatistics • 4+ years beyond M.S. • Work is varied; involves real discovery at the frontiers of science; typically fascinating!

  34. 往往最重大的決定是最不經意之間作出的。 換句話說：我們花了很多的時間去考慮一些雞毛蒜皮的事情，而真正需要花時間思考的時候，我們往往很輕率。 轉專業涉及到你的人生規劃，涉及到今後的發展，我們必須仔細思考。 切忌隨波逐流。 在此之前要提醒各位：

  35. 3 3 1 3 學科興趣 2 生涯規劃 多元智能 4 個性特徵 我所基於的四點理由：

  36. So, Do You Want to be a (Bios) statistician? cookieee0626@hotmail.com

  37. Backup slides

  38. 九十七學年度統計類研究所入學考試科目

  39. 留學英國- 英國研究所的特色 Masters Degree 碩士學位課程 碩士學位 (Taught Master’s 授課式) 皆可於1 年內修業完成 (MA, MBA,MSc, MEd, LLM) :1 year (3 terms) Doctorate 博士學位課程 Traditional PhD 傳統博士課程 : 3 years minimum

  40. 2009春季英國教育展 台北- 世貿一館 3月7日 (六)1300～18003月8日 (日) 1300～1800 主辦單位: 英國文化協會 更多資訊請瀏覽 www.britishcouncil.org.tw

  41. Why Study? The more you study, the more you learn. The more you learn the more you know. The more you know the more you forget. The more you forget the less you know. Why STUDY?

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