Chromatin Modification. Reading Seminar in Computational Biology Naomi Habib 5.1.2006. Chromatin Structure. Nucleosome (histone octamer wrapped with 146 bp of DNA). Chromatin Roles. Compactization Packing ~2 meters of DNA in to a ~10 micron diameter nucleus.
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Reading Seminar in Computational Biology
Naomi Habib 5.1.2006
Nucleosome (histone octamer
wrapped with 146 bp of DNA).
Dmitry K. Pokholok, Christopher T. Harbison,
Stuart Levine, Megan Cole, Nancy M. Hannett, P. Alex Rolfe, Elizabeth Herbolsheimer,Julia Zeitlinger,Fran Lewitter, David K. Gifford,and Richard A. Young.
Cell, August 2005
Model: transcriptional activators recruit Gcn5 and Esa1 to promoters of genes upon their Activation (Robert et al., 2004) .
model: Set2 is recruited by the elongation apparatus and that it methylates during active transcription.
Bradley E. Bernstein, Michael Kamal, Kerstin Lindblad-Toh, Stefan Bekiranov, Dione K. Bailey, Dana J. Huebert, Scott McMahon, Elinor K. Karlsson, Edward J. Kulbokas III, Thomas R. Gingeras, reStuart L. Schreiber, and Eric S. Lander.
Cell, January 2005.
(Me2>>3) ExpressionDi-,Tri-methylated H3K4
Systematic colocalization of methyl and acetyl marks reflect recruitment of complexes containing methylases and acetylases, and/or crosstalk between modifications.
cytokine and IL4R regions
HOXA cluster. ExpressionHOX clusters (continued)
-hybridizing RNA to the tiling arrays.