Chromatin Remodeling. *Cytosine Methylation*. Glossary. Epigenetic: Heritable changes in gene function, not caused by changes in the DNA sequence itself.
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Epigenetic:Heritable changes in gene function, not caused by changes in the DNA sequence itself.
CpG (island):Stands for Cytosine (P-bond) Guanine. Refering to a small region of DNA with a high frequency of CG sequences with respect to other regions.
Heterochromatin:Highly condensed, and transcription-suppressed sections of DNA
Housekeeping Genes:Undergo active transcription for basic cell functions.
DNMT:DNA Methyltransferase -1, 3a, 3b, L
H3K9:Lysine 9 of Histone 3
Suv39h:histone methyltransferase (H3K9)
MeCP/MBD:Methyl CpG Binding domain protein.
HDAC:Histone DeAcetylating protein
PcG:Polycomb Group (and repressor complexes)
EZH2, Eed, Su212:series of proteins that interact with PcG.
(Molecular Biology Web Book: 2005)
The removal of acetyl groups from histone
Loses neutral charge on molecule
DNA & Histone ModificationMethylation:
“A Simplified Description of DNA Methylation.” DNA Methylation Society. Oct 11, 2005. http://www.dnamethsoc.com/
Fuks, Francois. “DNA Methylation and histone modifications: teaming up to silence genes.” Current Opinion in Genetics. 15 (2005): 490-495
“ DNA Methylation and CpG Island.” Molecular Biology Web Book. 2005. http://www.web-books.com/MoBio/
“DNA Methylation.” Wikipedia, the Online Encyclopedia. 2005. http://en.wikipedia.org/wiki/DNA_methylation
“Epigenetics.” Wikipedia, the Online Encyclopedia. 2005. http://en.wikipedia.org/wiki/Epigenetic
“All HEPped Up about Methylation.” PLoS Biol 2(12): e433. November 23, 2004. http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0020433