1 / 16

Contents

Contents. Monolithic Process and Decision Errors Truth-seeking and Success-seeking It’s Time to Set Early-Stage Eli Lilly’s Chorus How Chorus Works Components of Chorus Conditions for an Early-Stage NPD Unit Conclusion. 1. Monolithic Process and Decision Errors.

april
Download Presentation

Contents

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Contents • Monolithic Process and Decision Errors • Truth-seeking and Success-seeking • It’s Time to Set Early-Stage • Eli Lilly’s Chorus • How Chorus Works • Components of Chorus • Conditions for an Early-Stage NPD Unit • Conclusion

  2. 1. Monolithic Process and Decision Errors Companies often treat new-product development (NPD) as a monolithic process, and make two types of decision-making error. Monolithic NPD Process Errors and the reasons Ignoring evidence challenging their assumption that a project will succeed Project is terminated prematurely forlack of evidence that it could succeed The power of champions to stir up collective faith in a project’s promise The human tendency to seek only evidence that supports our beliefs A failure to conduct the right experiments to reveal a product’s potential Organizational or personal biases against the project A shortage of resources

  3. 2. Truth-seeking and Success-seeking NPD process can be more rationally divided into two distinct stages: a truth-seeking early stage and a success-seeking late stage. Truth-seeking early stage Success-seeking late stage Evaluating novel products’ prospects and eliminating bad bets Maximizing the value of products that have been cleared for development Errors are eliminated

  4. 2. Truth-seeking and Success-seeking

  5. 2. Truth-seeking and Success-seeking

  6. 3. It’s Time to Set Early-Stage • Any company in an industry that relies on NPD for growth must avoid both kinds of errors promoted by focusing disproportionately on late stage development; they lack the early, truth-seeking functions whose explicit job is to head off such errors. • This requires encouraging: a willingness to kill a product early and a willingness to persist until its potential is realized. • Because a late-stage mind-set dominates most innovation companies, creating an early-stage organization with its own objectives, governance, and operations often requires a fundamentally new way of thinking.

  7. 4. Eli Lilly’s Chorus • Eli Lilly is the 10th largest pharmaceutical company in the world. • In 2001 it designed and piloted Chorus, an autonomous experimental unit dedicated solely to early-stage drug development.

  8. 5. How Chorus Works Goal Reducing uncertainty quickly and inexpensively Early stage • Processes • Defining what data are required to change the probability of success • Designing the simplest clinical trials that will provide such data • Executing the trials cost-effectively • Evaluating the data objectively • Delivering a recommendation to either continue or terminate development Chorus 20% to 40% Late stage 70% to 90% MarketLaunch

  9. 4. Cost of Chorus • It may impede parallel processing or concurrent engineering and defer scale-up and commercialization of products that will ultimately prove successful. • Nonetheless, the net benefit may be substantial. In large pharmaceutical firms, 80% to 90% of drug candidates that enter clinical trials will never launch; therefore, early investment in large-scale processes usually does not pay off.

  10. 6. Components of Chorus - Structure • Its structure is for efficiency and it resulted in flexible capacity and reinforcing truth-seeking by injecting dispassionate outside perspectives 24 Staff15 of whom aresenior scientists Chorus 15 9 75 external vendors provide most of the manufacturing,toxicology, and clinical workthe unit requires A network of 50external experts advise on topics such asexperimental designand drug delivery

  11. 6. Components of Chorus - Software Portfolio It tracks the impact of different experiments on probability of launch • The considerably complex job of managing the work of vendors and outside experts with minimal in-house staff is facilitated by a suite of software tools, known as Voice. • Planning • It integrates the opinions of external content experts • Operations • It organizes work according to subject area and distributes tasks and associated documents throughout the network

  12. 7. Conditions for an Early-Stage NPD Unit • The approach is not just a form of process reengineering. • They will have to create a new, separate organization that focuses on truth seeking. • A small team must be selected to plan, implement, and manage that organization. • The team builds the infrastructure and recruits both internal staff and consultants, who may bring essential expertise and objectivity to the project. • Being able to ask the right questions and design the critical experiments to rule in or rule out a product’s key attributes are essential skills for people in Chorus. • Teams within the unit are small and fluid, composed of individuals motivated by intellectual curiosity. • Each team member works on several products simultaneously, and of course, no one will follow any of the products into later stages.

  13. 7. Conditions for an Early-Stage NPD Unit

  14. 8. Conclusion • When development costs are high and failure is common, companies should structure research to seek truth first, success second. • As the early-stage organization develops its unique capability, it will work in parallel with the established NPD operation. • It offers additional capacity but does not replace existing NPD functions. • The goal for any early-stage organization and for R&D overall should be to head off costly downstream attrition of unpromising projects.

  15. Q&A

More Related