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Table 1. ADNI Autopsy Rates 09-01-2005 to 07-02-2010

Table 1. ADNI Autopsy Rates 09-01-2005 to 07-02-2010. Note: The ADNI-NPC was established on 9/1/2007. During the initial stage of ADNI1 the NPC had not been established and no autopsies were performed on the 6 ADNI participants who expired during 2007 and the first half of 2008.

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Table 1. ADNI Autopsy Rates 09-01-2005 to 07-02-2010

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  1. Table 1. ADNI Autopsy Rates 09-01-2005 to 07-02-2010 Note: The ADNI-NPC was established on 9/1/2007. During the initial stage of ADNI1 the NPC had not been established and no autopsies were performed on the 6 ADNI participants who expired during 2007 and the first half of 2008. Autopsy rate = number of brain autopsies/total number of ADNI participants who died.

  2. Table 2. Clinical and Neuropathologic Diagnoses at Expiration Note: N, number of ADNI cases. AD, Alzheimer’s disease; AGD, argyrophilic grain disease; DAT, dementia of the Alzheimer type; DLB, dementia with Lewy bodies; MCI, mild cognitive impairment; TDP-43, TDP-43 proteinopathy in the medial temporal lobe. Mild small vessel disease (arteriolosclerosis and cerebral amyloid angiopathy) was a feature of all cases but none had infarcts.

  3. Future Plans • For ADNI sites that are not federally funded ADCs, ADNI should provide funds ($5,000?) to support autopsy coordinator • With ADCS, develop an ADNI autopsy brochure • ADNI MUST prioritize autopsies

  4. ADNI Neuropathology Core • Protocols and Support Documents Online: • https://adcs-adni.bbl.ucsd.edu/docs/studydocs/Neuropath%20Core • Contact: • John C. Morris, MD Director, Alzheimer's Disease Neuroimaging Initiative Neuropathology Core Tel. +1-314-286-2881 Fax. +1-314-286-2763 Email: morrisj@abraxas.wustl.edu • Nigel J. Cairns, PhD, FRCPath Co-Director, Alzheimer's Disease Neuroimaging Initiative Neuropathology Core Tel. +1-314-362-2386 Fax. +1-314-362-4096 Email: cairns@wustl.edu • Lisa Taylor-Reinwald, BA, HTL(ASCP) ADNI Neuropathology Core Coordinator Tel. +1-314-362-8079 Fax. +1-314-362-4096 Email: ltaylor@pathology.wustl.edu • After office hours pager:+1-314-841-4738

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