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Completion of Skeletal Muscle and comparison to Smooth Muscle. Outline. Classification of Skeletal muscle Slow twitch versus fast twitch Oxidative versus glycolytic Skeletal Muscle Genetic Diseases Smooth Muscle Types of smooth muscle cells Smooth muscle contraction

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Completion of Skeletal Muscle and comparison to Smooth Muscle


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    1. Completion of Skeletal Muscle and comparison to Smooth Muscle

    2. Outline • Classification of Skeletal muscle • Slow twitch versus fast twitch • Oxidative versus glycolytic • Skeletal Muscle Genetic Diseases • Smooth Muscle • Types of smooth muscle cells • Smooth muscle contraction • Smooth muscle relaxation • Smooth muscle compared to Skeletal Muscle

    3. Classification of skeletal muscle • Speed of contraction • Resistance to Fatigue

    4. Which type of muscle fibers are used for these two activities? Pianist Weight lifting Fast Twitch Slow Twitch

    5. Muscular Disease • Muscular Dystrophy • Sex linked recessive • Dystrophin is mutated • Myasthenia Gravis • Decreased number of acetylcholine receptors

    6. TYPES OF SMOOTH MUSCLE CELLS

    7. SMOOTH MUSCLE CONTRACTION NO SARCOMERES! Presence of Dense Bodies EXTRA CALCIUM STORAGE SITES

    8. SMOOTH MUSCLE CONTRACTION at the MOLECULAR LEVEL • No sacromeres • No troponin

    9. Look inside the smooth muscle cell

    10. Smooth Muscle Relaxation

    11. Increase cytosolic calcium Calcium binds calmodulin Ca++Calmodulin activates MLCK MLCK activates myosin ATPase Shortening Increase of cytosolic calcium Calcium binds troponin Alteration in troponin moves tropomyosin Myosin binds actin Shortening Comparisons: Smooth versus Skeletal