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Essentials of Pathophysiology. Chapter 30 Disorders of Hepatobiliary and Exocrine Pancreas Function. The liver does not play a role in glucose homeostasis. Jaundice results from an abnormally high accumulation of bile in the blood.
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The __________ cells are capable of removing and phagocytizing old and defective blood cells, bacteria, and other foreign material from the portal blood as it flows through the sinusoid.
The sinusoids empty into central veins, which send the blood to the hepatic vein and inferior vena cavaLiver Structure
Hepatic cells lie along the sinusoids and pick up chemicals from the blood
They modify the blood’s compositionLiver Structure(cont.)
The bile is carried to the bile duct and then to the gallbladderLiver Structur e(cont.)
The section of the liver emptying into one vein is a lobuleLiver Structure (cont.)
The gallbladder stores bile that has been produced by the liver.Question
Which of the following substances does bile make more susceptible to digestive enzymes?
Ms. B was prescribed an oral medication for her skin problem. She took it twice a day.
Hematologic disorders as the liver fails the spleen takes over some of the function of the liver
Rationale:Erythrocytes are normally broken down in the spleen at the end of their life span. The end product of RBC metabolism is bilirubin. Bilirubin is sent to the liver to be metabolized; if the liver is not functioning properly, the bilirubin accumulates and causes jaundice (an abnormal yellowing of the skin and mucous membranes).Answer
Varicosities and shunts develop
Organs engorge with bloodVeins Draining into the Hepatic Portal System
The liver converts bilirubin into bile
Why would a man with liver failure develop jaundice?The Fate of Bilirubin
liver links it
Common bile duct
Ampulla of Vater
Sphincter of Oddi
juices through a
into the blood
The exocrine pancreas produces insulin.Question
5. Bile in pancreas disrupts tissues; digestive enzymes activated
1. Gallbladder contracts
2. Bile is sent down common bile duct
3. Blockage forms in ampulla of Vater: bile cannot enter duodenum
4. Bile goes up pancreatic duct