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Glycolysis, Krebs Cycle, and Electron Transport System

Glycolysis, Krebs Cycle, and Electron Transport System. A review for the confused (like me!) Regina Lamendella AP Biology December 16, 2008. What is happening while you ingest donuts??. Doughnut = glucose = electrons. What is the purpose of glycolysis and cellular respiration?. = Electrons.

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Glycolysis, Krebs Cycle, and Electron Transport System

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  1. Glycolysis, Krebs Cycle, and Electron Transport System A review for the confused (like me!) Regina Lamendella AP Biology December 16, 2008

  2. What is happening while you ingest donuts??

  3. Doughnut = glucose = electrons What is the purpose of glycolysis and cellular respiration? = Electrons

  4. Overview Video • Write down the major “take home messages” from the video

  5. Glycolysis • 10-STEP reaction • (Rxns 1-5) Glucose is phosphorylated and cleaved to yield 2 molecules of triose glyceraldehyde-3-phosphate. This process uses two ATPs. • (Rxns 6-10): The molecules of glyceraldehyde-3-phosphate are converted to pyruvate, with concomitant generation of four ATPs and two NADH per glucose. • How many net ATPs?

  6. Glycolysis 1 ATP • Where are we within the cell? • What does ATP stand for? • What does NAD stand for? • How many carbons does pyruvate have? 1 ATP 2 NAD+

  7. Adenosine Tri-Phosphate

  8. Nicotinamide Adenine Dinucleotide

  9. Nicotinamide Adenine Dinucleotide H H

  10. Overall reaction for glycolysis Glucose + 2 NAD+ + 2 ADP + 2 Pi  2 NADH + 2 pyruvate + 2 ATP Where do the pyruvate go next?

  11. Intermediary Reaction • Pyruvate (3-Carbon) Acetyl (2-Carbon)-CoA • 2 Pyruvate + 2 CoA + 2 NAD+2Acetyl-CoA + 2 CO2 + 2 NADH

  12. Overall energy production so far… • Glycolysis: 2 ATP, 2 NADH • Intermediate reaction: 2 NADH

  13. Kreb’s Cycle • Roles of the Krebs cycle • Generate energy by oxidizingacetyl-CoAto carbon dioxide and water • Supply biochemical intermediates for other pathways • Entry point of various degradative pathways for energy generation acetyl-CoA Squeezing the energy out of acetyl-CoA!!!

  14. Krebs Cycle • Where are we? • What is ATP? • What is NAD? • What is FAD? • How much energy is produced?

  15. FADFADH2Flavin Adenine Dinucleotide H H 

  16. Energy Production from Krebs Cycle Acetyl-CoA + 3 NAD+ + ADP + Pi → 3 NADH + ATP + 2 CO2 Wait we had two pyruvates to start… have to multiply above by 2!! 2 Acetyl-CoA + 6 NAD+ + 2 ADP + 2Pi → 6 NADH + 2 ATP + 4 CO2

  17. Energy Production So far… • Glycolysis: 2ATP, 2 NADH • Intermediate Step: 2 NADH • Kreb’s Cycle: 2 ATP, 6 NADH, 2 FADH2 • Where to next?

  18. Electron Transport System Video • Take notes and write down main points.

  19. Electron Transport System • Electron transport chains are redox reactions that transfer electrons from an electron donor to an electron acceptor. • The transfer of electrons is coupled to the translocation of protons across a membrane, producing a proton gradient. The proton gradient is used to produce useful work. NADH= 3 ATP FADH2= 2 ATP

  20. Total energy production after ETC • Glycolysis: 2ATP; 2 NADH= 6 ATP • Intermediate step: 2 NADH= 6 ATP • Krebs: 2 ATP; 6 NADH =18 ATP; 2FADH2 = 4 ATP • 34 ATP from ETC • 2 ATP from Glycolysis • 2 ATP from Kreb’s directly • Total ATP production= 38 ATP

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