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Formation of a Concentrated Urine. ADH present. 900. Na + Cl -. 1100. Fig. 23.19 modified . Antidiuretic Hormone in the formation of a concentrated urine. principal cell. Koeppen and Stanton, Renal Physiology . Medullary Gradient. two solute hypothesis NaCl urea

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formation of a concentrated urine
Formation of a Concentrated Urine

ADH present

900

Na+

Cl-

1100

Fig. 23.19

modified

antidiuretic hormone in the formation of a concentrated urine
Antidiuretic Hormonein the formation of a concentrated urine

principal cell

Koeppen and Stanton, Renal Physiology

medullary gradient
Medullary Gradient
  • two solute hypothesis
    • NaCl
    • urea
  • formation of gradient inhibited by
    • osmotic diuresis
      • The presence of unreabsorbed solutes decreases the concentration of Na+, thereby decreasing the reabsorption of Na+.
    • protein deficiency
      • less urea  smaller medullary gradient
    • loop diuretics
functions of adh
Functions of ADH
  • Formation of a concentrated urine
    • increased permeability of collecting duct to H2O
    • increased permeability of collecting duct to urea
    • increased reabsorption of NaCl by thick ascending limb of the loop of Henle
regulation of adh secretion
Regulation of ADH Secretion

Stimulates hypothalamic

osmoreceptors

 firing of

atrial

stretch

receptors

Fig. 24.4

Fig 24.3

diuretics summary
Diuretics Summary

Katzung, Basic and Clinical Pharmacology