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Transgenic Animals. By: Amber, Catherine, Kayla, Lauren. What is a transgenic animal ?. A transgenic animal is animal whose chromosomes have been changed to carry the genes of other organisms . How are (they) transgenic animals made ?.

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Transgenic Animals

By: Amber, Catherine, Kayla, Lauren


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What is a transgenic animal?

  • A transgenic animal is animal whose chromosomes have been changed to carry the genes of other organisms.


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Howare(they) transgenic animals made?

  • There are three main ways to produce transgenic animals: microinjection, blastocyst injection, and the help of a retrovirus.


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Microinjection:

  • This involves injecting a trangene, the gene used to create a transgenic animal, into a fertilized egg.

  • There is little ability to determine where the transgenic is located and whether it will survive.

  • Because of this, most eggs do not survive or do not have the transgene, but between 1% and 30% of the eggs injected can produce a live transgenic animal.


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Blastocyst Injection:

  • This involves placing the transgene into an embryonic stem cell or ES cell.

  • ES cells are cells that are able to develop into all types of tissues.

  • The cells are injected into blastocysts, which is an early stage of development. The injected ES cells become part of the animal and the animal becomes a mixture of transgenic and original cells.


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Help of a Retrovirus:

  • A retrovirus is a virus that can insert itself into a host’s chromosomes.

  • This virus is inserted into the cells.

  • The animals that contain the virus must breed to produce a transgenic animal.


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Why are (they)transgenic animals being made?

  • Transgenic animals are being made to help economic traits, be used as disease models, and help in medical research.


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Economic Traits:

  • Scientists created cattle to produce milk containing certain human proteins which may help in the treatment of emphysema.

  • It also helps in breeding. Farmers can produce transgenic animals that have the needed traits for doing a specific job.


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Disease Models:

  • Scientists are creating animals with specific human diseases and cancers, so that they can study the affects it has on the body. They hope this will help them find a cure for the different diseases and cancers.


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Medical Research:

  • Every year people die because of lack of a replacement heart,liver, or kidney.

  • Transgenic pigs may be able to supply these organs.

  • Research is trying to find a way to remove a pig protein and replace it with a human protein.


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Collageon Photostory

Dolly



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Credits

  • Info from:

    • Transgenic Animals by Dag Marcus Eide

    • The Virtual Embryo

    • Action Bioscience

  • Pictures from:

    • RNC Home

    • Green Florescent Protein

    • Belligerati

    • Living the Scientific Life

    • Geocities

    • Matching Making

    • Zoological Sciences

    • Gurdon Institute

    • Guelph

    • Pittsburg Development Center

    • Papilio

    • EnviroZine

    • 2 Day Blog

    • University Animal Care

    • BBC