Past iGEM Projects: Case Studies. 2006 Projects:. Neat Gadgets University of Arizona: Bacterial water color BU: Bacterial nightlight Brown: Bacterial freeze tag, tri-stable toggle switch University of Calgary: Dance with swarms Chiba University, Japan: Swimmy bacteria, aromatic bacteria
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Activator molecule A1
A1 binding site
(NH2)2CO + H2O = CO2 + 2NH3
R1 binding site
Repressor molecule R1
Repressor gene R1
Ars regulator 1
Ars regulator 2
Goal: Mimic natural tolerance to bacterial infections by building a feedback loop in TLR signaling pathway, which would decrease the overwhelming response to the persistent or repeated stimulus with Pathogen Associated Molecular Patterns (PAMPs).
PAMPs TLR MyD88 IRAK4 NFκB cytokines