London in the E.A.. Largest city in EuropeCenter of trade and social life because of the ThamesSo many migrants, jobs were scarce. Negative Aspects of London. High Drinking Rate. Beer was cheap, so people drank a lot of it to escape their problemsMany deaths by drunkenness. Sickness and Disease. 3 Main Diseases:Bubonic PlagueSmall poxTuberculosis.