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Managing Evidence at the Speed of Change. Tonya Hongsermeier, MD, MBA Corporate Manager, Clinical Knowledge Management for Decision Support Clinical Informatics Research and Development, Partners Healthcare System. Outline. New Market Demands for Evidence-based Practice

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managing evidence at the speed of change

Managing Evidence at the Speed of Change

Tonya Hongsermeier, MD, MBA

Corporate Manager,

Clinical Knowledge Management for Decision Support

Clinical Informatics Research and Development,

Partners Healthcare System

outline
Outline
  • New Market Demands for Evidence-based Practice
  • Challenges and Opportunities of Integrating Evidence-based Decision Support with the Electronic Health Record
  • The Partners Healthcare Model for Managing Evidence at the Speed of Change
current state of translating evidence into practice
Current State of Translating Evidence into Practice
  • 17 year innovation adoption curve from discovery into accepted standards of practice
  • Even if a standard is accepted, patients have a 50:50 chance of receiving appropriate care, a 5-10% probability of incurring a preventable, anticipatable adverse event
  • The market is balking at healthcare inflation, past utilization management measures have not succeeded

Carolyn Clancy, MD, Dir. AHRQ

Gandhi et al, NEJM 2003;348(16):1556-1564

Gurwitz et al, JAMA 2003;289:1107-16

McGlynn et al, NEJM 2003;348(26):2635-45.

slide4

Employers and consumers are now paying for performance

  • They will not wait for the data to be right or fair because they believe if they wait, it never will be
  • Instead, they are using the process of rewarding performance to force the healthcare providers to “make the data right”
  • Defined Contribution lays even greater purchasing responsibility at the door of the consumer
computer based clinical decision support
Computer-Based Clinical Decision Support
  • Not a panacea, doesn’t substitute for organizational alignment required for bringing evidence to practice, but when done well….
  • 55-83% decrease in hospital non-intercepted serious ADEs using CPOE
  • 22-78% increased adherence to preventive health reminders
  • At Partners, proprietary Drug-Drug Interaction checking intercepts 5% of physician orders, physicians change their decision about 33% of time
  • Kaushal R, et al. Arch Intern Med. 2003

Bates, JAMA 1998

And Unpublished

the volume and velocity of knowledge processing required for care delivery grows
The Volume and Velocity of Knowledge Processing Required for Care Delivery Grows
  • Medical literature doubling every 19 years
  • 2 Million facts needed to practice
  • A typical drug order today, decision support accounts for, at best, Age, Weight, Height, Labs, Other Active Meds, Allergies, Diagnoses
  • Already, there are 3000+ molecular diagnostic tests on the market, genomics and personalized medicine will increase the speed of change of evidence exponentially

Covell DG, Uman GC, Manning PR.

Ann Intern Med. 1985 Oct;103(4):596-9

slide7

When do you order this test?How do you use the test result?

Leading the News: Roche Test Promises to Tailor Drugs to Patients --- Precise Genetic Approach Could Mean Major Changes In Development, Treatment

June 25, 2003

Roche Holding AG is launching the first gene test able to predict how a person

will react to a large range of commonly prescribed medicines, one of the biggest

forays yet into tailoring drugs to a patient's genetic makeup.

The test is part of an emerging approach to treatment that health experts

expect could lead to big changes in the way drugs are developed, marketed and

prescribed. For all of the advances in medicine, doctors today determine the

best medicine and dose for an ailing patient largely by trial and error. The

fast-growing field of "personalized" medicine hopes to remove such risks and

alter the pharmaceutical industry's more one-size-fits-all approach in making

and selling drugs.

when knowledge changes
When Knowledge Changes…

How quickly can you change the content of your rules, order sets, templates, and reports?

clinical decision support challenges
Clinical Decision Support Challenges
  • How do we supply meaningful decision support that both improves quality of care for patients and quality of life for clinicians (and self-managing patients)?
  • How do we affordably develop, acquire and maintain the knowledge bases required to deliver meaningful decision support?
three facets of clinical decision support
Three Facets of Clinical Decision Support

Quality Performance

Evidence, Safety

Process Requirements

Regulatory Requirements

Improvisation

Patient Preferences

User Quality of Life

End-user role, workflow preferences

typical vendor system challenges
Typical Vendor System Challenges
  • Task-interfering approach to decision support - Siskel and Ebert Model
  • Editors don’t support “content vetting” process or the development of disease management approaches
  • Labor of developing and maintaining decision support knowledge is vastly underestimated
  • Consequently, clinical systems implementations are under-resourced with adequate knowledge to meet workflow and quality needs
new opportunities
New Opportunities
  • Content suppliers are emerging for decision support content:
        • Primarily order sets and some rules
        • Zynx, Wolters-Kluwer, Micromedex
  • New systems are available to support the vetting process without required attendance at committee meetings
  • New systems are available that make it possible to manage knowledge at the “goal level”
        • Manage Diabetes or Coronary Artery Disease related knowledge rather than managing just rules or order sets or documentation templates
partners has a long track record in applied clinical decision support
Partners has a long track-record in applied clinical decision support
  • Physician-oriented Drug-Drug Interaction Checking
  • Inpatient interactive order rules and notification alerts
  • Inpatient templated orders (hundreds)
  • Proactive Dosing support for Geriatric, Pediatric, Neonatal, Renally-Impaired, and Heme-Onc populations
  • Radiology Ordering decision support
  • Preventive health reminders
  • Documentation templates
  • Disease management reports/dashboards (Diabetes, others to follow)
  • Outpatient drug-lab, drug-disease interactive reminders
heterogeneous infrastructure
Heterogeneous Infrastructure
  • 5 internally developed POE applications (inpatient and outpatient)
  • 3 versions of Meditech and Siemens POE
  • Despite this heterogeneity:
        • Many sites share common expert dosing services
        • Many sites share a common allergy repository
        • Moving toward common problem list and medication list over the next 2 years
  • Partners is very committed to maintaining high-quality common logic to support Evidence-based Practices
knowledge management strategic goals
Knowledge ManagementStrategic Goals
  • Reduce the cost and increase the speed of translation of clinical innovation and evidence into clinical practice
  • Proactive, anticipatory decision support -- avoid “interruptive” decision support
  • Improve Partners’ organizational effectiveness as a learning organization through data-driven performance improvement
  • Align knowledge assets with business, regulatory, safety and quality requirements, Only build what we cannot buy
  • Partners has created some of the best decision support in production in the world, the goal here is to keep the knowledge up to date
knowledge life cycle challenges
Knowledge Life-Cycle Challenges:

Committee, Department,

Researcher, or Other

Proposes to Implement Content

  • Governance and Stewardship

Guideline is Defined and Validated

  • Inadequate tools and personnel to support vetting and update of knowledge
  • Lack of transparency of knowledge already in production
  • Bottlenecks the time it takes to agree on content

Functional Knowledge Specification

For Encoding is

Designed and Validated

Specification is

Engineered into Production Generating

a Technical Specification

  • Project and resource competition with other engineering projects, prioritization processes unclear
  • Editors inadequate
  • Lack of access to analytic data available on decision support content orimpact on clinical outcomes impact to direct updating
  • No content management tools to support process and ensure timeliness

Ongoing Revisions or

Eventual Sunset

Of Encoded Guideline

tactics we have deployed
Tactics we have deployed:

Transparency and Governance (2004):

  • Build and deploy a document library to provide enterprise wide access to information about of decision support knowledge in production
  • Worked with existing committees to evolve more effective governance models for content

Collaboration and Content Life-cycle Tools (2005):

  • Collaboration Portals aligned with clinical goals of Partners
  • Content Management infrastructure to support content management processes using lifecycles and workflows (knowledge maintenance)

Content Editing Re-architecture (2006-7):

  • Reduce the editing bottlenecks
  • Once decision is made for knowledge to change, change will be implemented rapidly
slide19

Clinical Content Committee:

Prioritizes and Sponsors Operational Stewardship of Content

Safety

Quality

Disease Management

Trend Management

Primary Care

Disease Areas

Pharmacotherapy

Imaging Studies

Adult, Geriatrics,

Pediatrics,

Women’s Health

CAD/CHF, Diabetes,

Heme-Onc, Asthma,

ID/HIV, Nephrology,

Psych

Medication

Knowledge

Committee

PCHI

P&T

MGH

ROE

BWH

Precipio

SME

Groups

Knowledge Analysts facilitate

Knowledge Editors update

Production Knowledge Repositories

the knowledge management portal can aggregate all content for coronary artery disease management
The Knowledge Management Portal:Can aggregate all content for Coronary Artery Disease Management
geriatric dosing case example of collaborative content development using documentum e room
Geriatric Dosing: Case Example of Collaborative Content Development using Documentum E-Room
  • New pay-for-performance incentive for Geriatric Prescribing at Partners
  • Gerios in production in one inpatient order entry system for several years, must deploy across the enterprise
  • Content review showed gaps (missing drugs) and need for update to accommodate all care settings
  • 160+ Row Decision Table not easily reviewed with Outlook, geriatricians don’t have time for meetings
  • Even if this is commercial content, tools like this are still needed for committee review
  • Outcome: successful review, updated geriatric dosing is now integrated with more order entry applications
slide23

Example:Setting aside the challenge of “who decides on content”,

This screenshot shows a common approach to decision support design:

MS office folders, documents related by title and common location only,

Difficult to know what changed from one version to next or why, people move

on to new jobs and folders get lost…..

Must maintain the “Metaknowledge”:

the who, what, when, where, and why about decision support content,

slide24

Partners maintains a geriatric dosing database that supports either default dosing more appropriate for geriatric population or substitution recommendations

slide33

E-room report illustrating aggregation of expert input,

dramatically improves efficiency for subject matter experts

and medication services design teams

Vioxx alert shared, removed from database

slide34

After updating the content in the medication knowledge base, updates are published quarterly to the portal to share across sites, and we are still working with vendors to achieve integration of Gerios dosing with Meditech and Siemens

diabetes case example of the knowledge editing challenge
Diabetes:Case example of the knowledge editing challenge
  • Epidemic, associated with obesity
  • Estimated avg $21,000/year per diabetic employee in absenteeism, disability and medical costs (study of 6 employers with 375,000 employees)
  • HEDIS measures drive reimbursement
      • Maintain HbA1c <7 (diet, oral agents and/or insulin)
      • If Renal Disease and no contraindication, should be on ACE inhibitor or ARB
      • If lipid disorder and no contraindication, should be on a statin like lipitor
methodology
Methodology
  • Identify relevant guidelines to achieve a given measurement goal
  • Decompose guidelines into the draft components for rules, documentation templates, order sets, and reporting
  • Evaluate feasibility of current EHR system to deploy
  • Determine what content can be purchased
  • Establish baseline performance
  • Implement content
  • Re-measure and refine
editing evidence into clinical decision support
Editing Evidence into Clinical Decision Support --
  • Imagine a HEDIS measure:
        • Patients with Diabetes and Renal Disease or Hypertension should be on an ACE inhibitor or ARB unless there is a “contraindication”
  • Must define who has Diabetes, Renal Disease and Hypertension (problems, documentation, medications, test results)
  • Define “Contraindication to ACEi or ARB”
        • Allergy,
        • Cough symptom on adverse reaction list
        • Hyperkalemia on problem list or high K test result
        • Pregnancy (Many components)
        • Patient refuses
        • Must be the same in rules, documentation templates, and reporting tools
slide38

Composite Decision Support Application: Diabetes Management

Guided Data Interpretation

Guided Observation Capture

Guided Ordering

managing change across content types across silos
Managing change across content types, across silos
  • The rate of change for contraindication definition today is very slow, it’s a challenge for most EHRs to provide decision support for this
  • With the advent of molecular medicine, this rate of change could become daily
  • Our approach to build a knowledge staging infrastructure that enables our editors to manage propagation and inheritance across related content areas
  • Change in one content area can trigger notifications to edit related content or to validate and automate propagation to relevant content
slide40

Conceptual Architecture for Knowledge Management

Knowledge Management Staging Area

eRoom Content Vetting and Content Editing Portals

3rd Party

Content

NDDF

Zynx

Micromedex

Clineguide

Etc.

Knowledge Search, Retrieval, and Reporting Services

Editors

Collaboration

Services

Meta-

Knowledge

Rules, Templates, Reports

Validation & Integration

Complex Definitions

Health Language Inc. Terminology

Documentum Content Management Server

Documentum

Deployment Agent

Quality Data Management

Knowledge Repositories

Transaction

Knowledge Repositories

Partners Services

And Applications

Web

Service

Lookup

Production Knowledge Bases

managing evidence at the speed of change41
Managing Evidence at the Speed of Change
  • Requires strong leadership commitment to invest in knowledge, people and systems to manage knowledge
  • Health systems vendors will need to vastly improve their capabilities to support knowledge acquisition and usable decision support
  • Standards for content representation and interoperability remain a challenge, the current state benefits vendors and consultants
  • Market forces (aging, genomics, pay-for-performance) create decision support imperatives that will drive technology innovation
questions
Questions?

Never, ever think outside of the box!!!