Connective Tissue Disorders. Terminology. Collagen vascular diseases Auto immune diseases Rheumatology = study & treatment of diseases of immune system Examples: SLE JRA Dermatomyositis Vasculitides Ankylosing spondylitis. Immunological tolerance.
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Revised Diagnostic Criteria
Diagnose if 4 or more of the 11 criteria are present, serially or simultaneously, during any interval of observation
Adapted from Pathologic basis of disease 7th edition
Adapted from pathologic basis of disease 7th edition
Increased nailbed capillaries
Class IV induction (6 months) IV CYC or MMF
maintenance: MMF or AZA or quarterly IV CYC
Class V Glucocorticoid+/- (ciclosporin,AZA,MMF,CYC )
Class VI NO SPECIFIC THERAPY
Better safety profile than traditional immunosuppressive agents
NOVEL THERAPEUTIC APPROACHES
→ improved control of refractory vasculitis
→allowed lower steroid dosing in induction therapy
→benefit as induction therapy in refractory WG