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Enhancing Fine Needle Aspiration Procedure for Tissue Sampling Efficiency

The project aims to modify the needle used in Fine Needle Aspiration (FNA) procedures to increase tissue sample collection efficiency for cytological testing with minimal patient discomfort. The current 23-gauge needle is preferred over the standard 20-25-gauge. Prototype testing on various tissues and comparison between old and new techniques have shown promising results. Future work includes material research, protocol development, and in vivo testing on animal tumors.

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Enhancing Fine Needle Aspiration Procedure for Tissue Sampling Efficiency

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  1. Problem Statement GOAL:To modify the needle used during a Fine Needle Aspiration (FNA) procedure. The modification should not drastically change the FNA procedure and still increase the amount of tissue removed for cytological testing. It should also minimize the time (by collecting an adequate sample size on the first attempt) and discomfort caused to the patient during the procedure.

  2. What is FNA? • Technique used to extract cells; no incision needed • Several insertions are usually required to ensure an adequate sample size • Samples are sent to pathologist to be analyzed National Breast Cancer Center, http://www.NBCC.org

  3. Fine Needle Aspiration (FNA) A.D.A.M., http://www.adam.com

  4. Product Design Specifications • Removes adequate number of cells for diagnosis. • Should not cause more discomfort than current FNA procedure. • Constrained to standard 20-25-gauge needle, client prefers 23-gauge.

  5. Current Prototype • Pre-manufactured drill bit • 6” length • Fits in 23 gauge needle

  6. Tissues Tested • Fixed cat tissues • Mammary • Lymph • Fat

  7. Testing Procedures • Old technique • No insert used • Performed two separate trials on all three tissues • New technique • Drill bit insert used • Performed two separate trials on all three tissues • Observed in saline bath under microscope

  8. Sample Quantification • Old technique • Resulted in either a mass of cells or a minimal quantity of cells • New technique • More dispersed cell sample • Greater number of cells on average

  9. Future Work • Further prototype development • Research into appropriate materials to be used (stainless steel, Co-Cr, Ti) • Develop protocol for quantifying testing • Test on freshly removed tissue • In vivo testing of animal tumors • Cytological evaluation

  10. Drill Bit Size Comparison

  11. Tissue Sample- Mammary

  12. Tissue Sample- Lymph

  13. Tissue Sample- Fat

  14. Old Technique- Mammary

  15. Old Technique- Lymph

  16. Old Technique- Fat

  17. New Technique- Mammary

  18. New Technique- Lymph

  19. New Technique- Fat

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