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Efficient Hydrogenation of Pyrroles for Synthesis of Drug-Like Complex Amines

This research presents an efficient method for the hydrogenation of pyrroles, utilizing 5% Rh/Al2O3 in a methanol/ethanol mixture under mild reaction conditions (1-10 atm H2 at room temperature). The process yields chiral amino acids and complex structures with drug-like properties, achieving a remarkable yield ranging from 75% to 95%. This method offers a straightforward pathway to access valuable pharmaceutical intermediates, highlighting its potential for further applications in organic synthesis.

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Efficient Hydrogenation of Pyrroles for Synthesis of Drug-Like Complex Amines

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  1. Hydrogenation of Pyrroles: An Efficient Method for Synthesis of Complex Structures druglike molecules amines Reaction Conditions: 1-10 atm H2 5% Rh/Al2O3 MeOH/EtOH; rt yields= 75-95% chiral amino acids

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