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PDX1 MED

Notch signaling. Exocrine Transcription. Intestinal Transcription. Suc/Isom. Amylase. IFABP. Jagged1. Jagged2. Dll1. Gut. ?. Gut. Gut. MIST1. Wnt /b- cat. Cdx1. GATA4. ?. Notch1. Notch2. Cdx2. Gut. ?. Ptf1a. Hes1. nr5a2. ?. Core Endodermal program.

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PDX1 MED

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  1. Notch signaling Exocrine Transcription Intestinal Transcription Suc/Isom. Amylase IFABP Jagged1 Jagged2 Dll1 Gut ? Gut Gut MIST1 Wnt/b-cat. Cdx1 GATA4 ? Notch1 Notch2 Cdx2 Gut ? Ptf1a Hes1 nr5a2 ? Core Endodermal program Pancreas Determination Endocrine fate Allocation Endoderm Establishment GATA6 Oct4 HNF1a HNF4 HlxB9 ? Sox9 ? Via Sox17 or Mix? Six3 ENDODERM SMAD2/SMAD4 /SMAD4 Ngn3-E2A FoxA2 PDX1MED Eye Via nkx2.2? X.L Nkx2.2 Activin or nrf Cell cycle Exit HNF1b HNF6 X.L Eye Sox17 NeuroD-E2A Prox1 FGF10 Indirectly Z.F Eye Nkx6.1 Z.F Eye COUP-TFII Mixer/Bon Casanova Hex Z.F Pax6 Pax4 Pax2 C/EBP-a Nodal Gut Pbx1 HNF1a Pax4 Pancreas FoxA2 Insulin PDX1HIGH FoxA3 Brn4 Glucagon Eye Gli2 SMAD1/SMAD4 /SMAD4/ Isl1 FoxO1 HNF4 LIVER TRANSCRIPTION FoxA1 BMP mafA < =? > L-Maf Also involving most members of the core endodermal program Shh Beta-cell Transcription Alpha-cell Transcription Symbols How to use this file: 1. Download file to disk. 2. Open File by double clicking. Select “slideshow” option in PowerPoint (PC: press F5). Within the slideshow, point-and-click on arrow, gene, or symbol for exiting to hyperlinked information. Hyperlink information will display when hovering over symbol. Clicking within non-linked areas will terminate the slideshow. Press F5 to resume slideshow. For best results, a 17’’ screen, or larger, is recommended. Documented interaction, positive Hyperlink, review on subject Documented interaction, negative Link demonstrated in Zebrafish Z.F Documented interaction, not in pancreas Link demonstrated in Xenopus Laevis X.L Autoregulation Hyperlink, description of targeted mutation of gene Suggested interaction, not proven Extra-cellular signaling Comment on auto-regulation arrows: Green: The gene acts by a self-sustainable mechanism – intrinsic stability of network Red: The gene may act by a threshold mechanism – intrinsic instability of network Comment on targeted mutation links: Studies of the genes by targeting mutations may have been performed by several independent groups, and several publications may exist regarding a particular gene. Furthermore, independent targeting may have been performed, as is the case for e.g. Pdx1, HB9, Ptf1a, NeuroD. Here, each link branches out only to one given study. Please consult the text for additional information to other references having provided information about the role of the gene in pancreatic development using a targeted mutation approach. Regulatory interactions during pancreatic development, obtained from Jan Jensen. Barbara Davis Center for Childhood Diabetes, U. Colorado Health Sciences Center.

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