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synaptic plasticity

DENT/OBHS 131 Neuroscience. synaptic plasticity. 2009. Learning objectives. Understand the properties of long-term potentiation (LTP) that define it as a model of experience-dependent synaptic plasticity

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synaptic plasticity

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  1. DENT/OBHS 131Neuroscience synaptic plasticity 2009

  2. Learning objectives • Understand the properties of long-term potentiation (LTP) that define it as a model of experience-dependent synaptic plasticity • Discuss the characteristics that make NMDA receptors coincident detectors cable of initiating associative information storage (Pavlov’s dog) • Describe the relationship between NMDA receptors, LTP and behavioral memory

  3. learning & memory in taxi drivers • PET study during recall of London route (Maguire et al, 1997)

  4. Papez circuit / loop

  5. place cells / maps • some pyramidal cells in the hippocampus (and other parts of Papez circuit) have preferred spatial orientations & place maps (O’Keefe & Dostrovsky, 1971)

  6. Hebbian learning….in theory • longer term plasticity • Hebbian learning • Hebb (1949) hypothesized that “ if one neuron frequently takes part in exciting another, some growth process or metabolic change takes place in one or both cells and the strength of their connection increases ”

  7. Synapses are plastic • synapses “remember” previous activity • short-term, e.g. post-tetanic potentiation at the nmj control motor neuron motor neuron pre nmj muscle muscle time post

  8. Can synaptic plasticity explain learning? • CS (neutral) - no response • US - UR • After pairing: • CS - CR

  9. Learning Objective #1 • Understand the properties of long-term potentiation (LTP) that define it as a model of experience-dependent synaptic plasticity

  10. Long-term potentiation (LTP) • first demonstration of LTP • high-frequency train • rapid induction • lasts weeks in vivo after before amplitude time (hrs) Bliss & Lomo (1973)

  11. properties of LTP

  12. Learning Objective #2 • Discuss the characteristics that make NMDA receptors coincident detectors cable of initiating associative information storage (Pavlov’s dog)

  13. cellular mechanisms underlying LTP • induction • maintenance

  14. excitatory synaptic transmission • NMDA vs non-NMDA • synaptic transmission AP5 control AP5

  15. LTP depends specifically on NMDA receptor activation • AP5 prevents high frequency-induced LTP (Collingridge et al, 1983)

  16. out +++ Mg+ Mg+ - - - in what is special about NMDA receptors? • voltage-gated channels: voltage • ligand-gated channels: transmitter • NMDA receptors: both + - +

  17. NMDA receptor: a molecular switch • co-incidence detector • requires both presynaptic activity (glutamate) and postsynaptic depolarization (relieve Mg block) • satisfies Hebbian co-incidence rules • explains LTP properties:

  18. how does the NMDA receptorcause a change in synaptic strength?

  19. synaptic transmission is unreliable • increased transmitter release • altered or new receptors • new synapses

  20. hippocampal “integrated circuit” Johnson & Wu (1995)

  21. associative pattern storage from McNaughton & Morris (1987)

  22. Learning Objective #3 • Describe the relationship between NMDA receptors, LTP and behavioral memory

  23. NMDA receptor-dependent learning spatial memory task visual task “Morris” water maze Morris et al (1990)

  24. LTP and learning • saturation of LTP prevents learning a new spatial task • new learning can occur after LTP decay LTP decay Castro et al (1989)

  25. diffuse storage in cortex? • computational theories • e.g., Marr (1970’s) • sensory input to neocortex • stored by association • repetition - association • partial pattern recall

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