1. LPA/HGF/AG1478 LPA LPA/AG1478 3xAP-1 Luc TK 30 20 DMSO AG1478 10 A 0 0.5 1 2 4 6 0 0.5 1 2 4 6 0 0.5 1 2 4 6 hr c-Jun 1 3.9 14.7 17.8 8.2 2.7 1 1.4 2.0 4.4 4.7 2.7 1 2.7 10.9 13.1 7.6 2.6 c-Fos vector EGFR-DN 1 23 63.7 68.6 44.5 18.5 1 2.3 8.8 11.2 2.2 1.1 1 21.3 52.6 54.2 36.5 15.4 EGFR-DN Ade control Ade Fra-1 LPA 0 2 0 2 hr LPA 0 0.25 0.5 1 2 0 0.25 0.5 1 2 hr 1 0.7 1.1 11.6 40.9 43.2 1 0.9 1.1 1.4 3.0 1.8 1 1.2 1.5 10.3 39.3 38.8 Jun-B c-Jun c-Jun 1 1.4 1.8 6.5 14.9 10.8 ND ND ND ND ND ND 1 1.2 1.6 5.7 14.7 14.7 c-Fos GSK-3a/b c-Fos EGFR Jun-B EGFR-DN Luc activity (fold) Fra-1 b actin EGFR * B EGFR-DN b actin LPA LPA control control C LPA LPA/AG1478 LPA/HGF/AG1478 0 0.5 1 2 4 0 0.5 1 2 4 0.5 1 2 4 hr