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About cardiovascular problems

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About cardiovascular problems

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  1. About Cardiovascular Problems

  2. Reactive Oxygen Species Reduction or oxidation caused by addition or loss of any electron is responsible for alterations in functional and structural profile of molecules, hence, changing signaling mechanism.

  3. Sources of ROS in cells The literature indicated that vascular cells, as well as cardiomyocytes and neurons, produceROS, contributing to the development of disorders related to the cardiovascular system.Althoughseveral enzyme systems produce ROS,

  4. ROS in the heart It is already known in the literature some mechanisms regarding the role of antioxidantsduringoxidative stress caused by ROS in the heart tissue. Among the enzymatic and non-enzymatic antioxidants involved in ROS-induced heart tissue injury we may includecatalase,

  5. ROS-Induced vascular damage ROS are involved in pathological and physiological processes in the vasculature. Enhancedarterialpressure is partially caused by enhanced total peripheral vascular resistance,Supports blood formulationwhichisdue to disorders of structural remodeling of blood vessels and vasomotor function.

  6. Oxidative stress in the kidney Renal artery obstruction can cause arterial hypertension, which is followed by impaired renalfunctionand renal atrophy. Cardiovascular disorders caused by kidney injury are in partregulatedby renin release from the stenotic kidney,

  7. The involvement of the nervous system Neurons in the brain present increased density of polyunsaturated fatty acids in its cellmembranes. Fatty acids are targets of free radicals. An indirect marker of ROS, TBARS isenhancedin the brainstem of SPSHR compared to age-matched control

  8. Models of ROS Basic science applied in animal is indispensable to comprehend the pathogenesis,mechanismsinvolved in therapeutic agents, molecular process, and environmental orgeneticfactors that increases the risks of disease development.

  9. peripheral vascular disease It is known that vascular diseases such as peripheral vascular disease, coronary arterydiseaseand cerebrovascular diseases are the largest cause of morbidity and mortality inindustrializedcountries.

  10. The effects of oxidative stress Many previous studies have already demonstrated cardiovascular problemsthe effects of oxidative stress on thecardiovascularsystem. Superoxide dismutase (SOD), an enzyme that catalyze the dismutationof O2ï− into oxygen and H2O2,

  11. Cardiomyocytesand Neurons The literature indicated that vascular cells, as well as cardiomyocytes and neurons, produceROS, contributing to the development of disorders related to the cardiovascular system.Althoughseveral enzyme systems produce ROS, many of them are prevalent in pathologicprocesses.

  12. Chronic heart failure There are several potential sources of ROS in the heart with chronic heart failure (CHF).Excessive ROS derived from mitochondria have been shown in cardiomyocytesfromexperimentalmodels of myocardial infarction and rapid pacing‐induced heart failure (Ide etal, 2001).

  13. ROS-inducedcardiovascular disorders. In summary, Figure 3 presents the main mechanisms involved in ROS-inducedcardiovasculardisorders. Many studies implicate ROS-generating NADPH oxidases inredoxsignaling in cardiovascular cells and involvement in pathological processes such ascardiachypertrophy, fibrosis, apoptosis and ventricular remodeling.

  14. Thanks For watching This Slide For More Informationhttp://afritradomedic.com

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