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Your first mentored grant proposal: The National Institutes of Health F and K proposals, and Foundations Alison K. Hall, PowerPoint Presentation
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Your first mentored grant proposal: The National Institutes of Health F and K proposals, and Foundations Alison K. Hall, Ph.D. Case School of Medicine Office of Graduate Education. You are at a critical juncture in training productive self-reliant about to embark on independent careers

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slide1

Your first mentored grant proposal:

The National Institutes of Health

F and K proposals, and Foundations

Alison K. Hall, Ph.D.

Case School of Medicine

Office of Graduate Education

slide2

You are at a critical juncture in training

productive

self-reliant

about to embark on independent careers

becoming physician-scientists

Often write a grant to seek financial support and recognition for research

slide3

Why do you want a mentored grant?

Makes the relationship with the PI explicit

Benefits associated with grant

Looks good on your resume

Great learning experience

The future inclues an R01…

slide4
The Number of Pre-Doctoral and Post-Doctoral Research Training Positions on NIH Training Grants and Fellowships (NRSA)Fiscal Year 2005
slide5

Where do you start?

Communicate

your PI, potential mentors

your chairperson

the Office of Research/ Univ Review, compliance

Are you ready?

pilot data

time to focus

deadlines

Do you qualify?

appointment status

US citizens, permanent residents

slide6

The Number of Research Training Positions on NIH Training Grants and Fellowships(NRSA) Fiscal Years 1996 - 2005

slide8

The F30 National Research

Service Award (NRSA) for individual

Predoctoral MD/PhD fellows

http://grants.nih.gov/grants/guide/pa-files/PA-05-151.html

set stipend scale and supplement

slide9

TheF32NRSA

Jan. 9, 2006 Stipends for Kirschstein-NRSA awards 2006

Postdoctoral

Years of Experience:

0 $36,996

1 $38,976

2 $41,796

3 $43,428

4 $45,048

5 $46,992  

6 $48,852  

7 or more $51,036

Institutional Allowance $5,500 Research supplies,

health insurance, travel to mtgs

Program announcements

http://grants.nih.gov/training/nrsa.htm

slide10

Components of Participating Organizations

National Institute on Aging (NIA/NIH), (http://www.nia.nih.gov/)

National Institute on Alcohol Abuse and Alcoholism (NIAAA/NIH), (http://www.niaaa.nih.gov) National Institute on Deafness and Other Communication Disorders (NIDCD/NIH), (http://www.nidcd.nih.gov)

National Institute on Drug Abuse (NIDA/NIH), (http://www.nida.nih.gov)

National Institute of Environmental Health Sciences (NIEHS/NIH), (http://www.niehs.nih.gov) National Institute of Mental Health (NIMH/NIH), (http://www.nimh.nih.gov)

National Institute of Neurological Disorders and Stroke (NINDS/NIH), (http://www.ninds.nih.gov) Office of Dietary Supplements (ODS/NIH), (http://ods.od.nih.gov)

April 5

August 5

December 5

Individual fellowships (F31) for minority students or students with disabilities have special receipt dates

slide11

TheF31NRSA

There are some 25 Institutes at NIH that each have mission

Look at CRISP database

http://crisp.cit.nih.gov/crisp/crisp_query.generate_screen

As director of the National Institute of General Medical Sciences from 1974 to 1993, Ruth Kirschstein MD was the first woman institute director at the National Institutes of Health (NIH). Throughout her career, she has worked as an administrator, fundraiser, and scientific researcher, investigating possible public health responses in the midst of crisis and conservatism.

slide12

Stipends 20,772 (suppplement)

Tuition and fees (formula)

Health insurance

Institutional Allowance 30 fellows receive an institutional allowance of $2,750 per 12-month period to non-federal, or nonprofit sponsoring institutions to help defray such awardee expenses as research supplies, equipment, books, and travel to scientific meetings.

slide13

The F32 NRSA is a reasonable goal:

2002 Number number total cost success

reviewed awarded awarded 1000s rate*

MD 202 91 4,602 45

  PHD 1,336 516 20,813 38.6

   all 1,538 607 25,415 39.5

http://grants.nih.gov/grants/award/training/F32MDPHD9502.HTM

slide14

Grant NumberPI NameProject Title

5F32GM074554-02ARMBRUSTER, BLAINECreation of designer biogenic amine receptors

5F30DC007274-02 BALU, RAMANIIntrinsic properties of olfactory bulb mitral cells

5F30NS050913-02 COWAN, THOMASAssistive Device Control With Brain Surface Signals

1F31NR008984-01A 2DIMARCO, MARGUERITEUtilization Dental Care by Homeless Children

5F30ES011931-04 ETLING, MICHELEInitiation of Experimental Colitis by Commensal Flora

5F31HD049326-02 JAGODNIK, KATHLEENUpper Extrem. Control Using Reinforcement Learning

5F31MH073296-02 LERCH, JESSICAMolecular Genetics of the Serotonin System

5F31NR009344-02 MURROCK, CAROLYNDance and Physical Activity in Afr. American Women

1F32AA015833-01 PRITCHARD, MICHELEEgr-1 and EtOH-induced hepatic leukocyte recruitment

5F31HD041926-04 ROHDE, TREENAPREDOC FELLOWSH FOR STUDENTS WITH DISABILITIES

5F31MH074241-02 SAMUELS, IVYERK2 Specific Function of the CNS

1F32CA115150-01A1 SWEENEY, COLINRetroviral Insertional Mutagenesis in LMO1 Stem Cells

5F32AG024031-02 WILKINSON, BRANDYMechanisms of Abeta-Stimulated ROS in Microglia

slide15

Prepare the Application: read the instructions!!

  • start early, seek internal reviewers
      • Candidate
      • US citizen or permanent resident
        • Doctoral degree (many ok)
      • Sponsor and Training Environment
      • Research Proposal

Up to 3 yrs

      • Training Potential-impt!
      • Vertebrate Animals, Human Subjects etc.
      • Three letters of reference
      • 3 times per year, usu Apr 5, Aug 5, Dec 5

The A1 or A2. You may have to resubmit…

      • http://grants.nih.gov/training/nrsa.htm
slide16

NRSA Review Criteria

  • Candidate:
    • previous academic and research performance
    • potential to become an important contributor
  • Sponsor and Training Environment:
    • quality of the training environment
    • qualifications of the sponsor as a mentor
      • for the proposed research training experience.
  • Research Proposal:
    • merit of the scientific proposal
    • relationship to the candidate's career plans.
  • Training Potential:
    • value of the proposed fellowship experience
    • as it relates to the candidate's needs in
    • preparation for a career as an independent researcher.
slide17

TheK08

Mentored Clinical Scientist Development Award

For clinically trained persons to pursue research careers in basic or clinical sciences.

Must apply within 3 years of clinical

Training (residency +1 year of clinical fellowship)

K08->K02-> R01

up to $85,000 salary up to $50,000 costs/ year

up to five years, non-renewable

slide21

TheK08

  • Prepare the Application: read the instructions!!
      • a. Candidate
      • b. Research Plan
      • c. Career Development Plan/ Training Plan
      • d. Environment/ Institutional support
      • e. Mentor*
      • f. Vertebrate Animals, Human Subjects etc.
      • The A1 or A2. You may have to resubmit…
      • (The summary statement)
slide22

TheK08

Candidate**

  • **some Institutes require faculty app’t (eg Instructor)

Basic Science Mentor/co Mentor:

    • Good working relationship
    • Often funded by NIH
    • Expert in this area
    • Experienced trainer
slide23

The K08

Career Development Plan (very important)

    • Focused and relevant
    • New techniques, new area, could be funded
    • Present at meetings, review grants, external courses
    • Update didactics
    • Create an oversight committee familiar with research, career goals, meet six mos for feedback
slide24

Research Plan

  • Provide preliminary data to support rationale,
  • approach. Focus!
  • Include study of Research Ethics, animals etc.
slide25

TheK08

http://grants.nih.gov/grants/guide/pa-files

See supplementary info at each institute

Insure protected time

-Do not assume that 75% means anything

except 75% of your total working hours

-These estimates are carefully reviewed

essential that your chair state this

not contingent on receipt of the grant

-50% Neurosurgery

slide26

What happens to your application after it leaves the mailbox?

Center for Scientific Review receives the application

assigned to the Initial review group or “Study section”

Review for SCIENTIFIC MERIT and TRAINING POTENTIAL.

Summary statement, see NIH Commons

Scores and percentiles. NRSAs are not streamlined

Priority score 100-500, with 100 is best.

Rewrite? Respond to critique

Funded?Progress report each year

slide27

Inside the NIH Grant Review Process

39 min video NIH Center for Scientific Review

Includes R01/K08/ R03

Download proposals

http://www.drg.nih.gov/Video/video.asp#docs

View the video on the web

http://www.drg.nih.gov/Video/Video.asp

Helpful Hints for an NLHBI K08 Application http://www.nhlbi.nih.gov/funding/training/redbook/hints.htm

slide28

Grantwriting Resources

Grantpersonship: An Instruction Manual

http://www.pitt.edu/~survival

NIMH Grant Application Process

http://www.nimh.nih.gov/researchFunding/grantprocess.cfm

http://www.nimh.nih.gov/researchFunding/training.cfm

FASEB Grantsmanship Training Program

https://ns2.faseb.org/careerutilities/grantprg.htm

Grant Application Writer’s Handbook, Reif-Lehrer

slide29

What about foundations and organization fellowships?

Public charitable organizations-

MDA, AHA, ACS

Derives support from members of the public

Foundations-Private, Corporate

derives support from a family, individual or corporation

see The Foundation Center

www.fdncenter.org/cleveland

(Richard Sohn, Research Admin has subscr.)

often have a disease focus

may support non US citizens

Often have one deadline per year

slide30

Where to find these other grants?

Grantsnet

http://sciencecareers.sciencemag.org/funding?CFID=380054&CFTOKEN=35995422

“Initial MD postdoc, dermatology, skin” examples:

18. LRF Postdoctoral Fellowship Awards Program

Sponsor: Medical Foundation

Program Type: Anatomy, Biochemistry, Bioengineering, Bioinformatics, Biology, Biophysics, Cell Biology, Chemistry, Developmental Biology, Immunology, Microbiology, Molecular Biology, Physiology, Structural Biology

Deadline(s): 11/15/2005

23. Research Grants

Sponsor: American Skin Association, Inc.

Program Type: Biology, Cancer, Cell Biology, Clinical Research, Developmental Biology, Disease-Specific Research Skin Cancer/Melanoma, Psoriasis, Epidemiology, Immunology, Molecular Biology, Structural Biology, Other (specify): Vitiligo, Childhood Skin Diseases/Disfigurement, Pigment Cell Biology and Auto-immune Inflammatory Skin Diseases

Deadline(s): 10/03/2005