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Chemical Products N-Hydroxysuccinimide Description

Chemical Products N-Hydroxysuccinimide Usage<br>Additive used in the carbodiimide method for improved amidations and peptide couplings.

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Chemical Products N-Hydroxysuccinimide Description

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  1. CAS No:6066-82-6 Formula:C4H5NO3 Synonyms: NHS;HOSU;HONSU;AKOS HONSU;Hydroxysuccinimide;N-HYDROXYSUCCINIMDE;N-HYDROXYSUCCINIMIDE;1-Hydroxysuccin imide 91864;NHS OR Categories: Pharmaceutical Intermediates > Anticonvulsants Chemical Products N-Hydroxysuccinimide Description White to pale yellow Chemical Products N-Hydroxysuccinimide Basic Attributes CAS No： 6066-82-6 Molecular Formula ： C4H5NO3 Molecular Mass ： 115.09 Exact Mass ： 115.026939 PSA ： 57.6 LogP ： -1.4 EINECS ： 228-001-3 InChIKeys ： NQTADLQHYWFPDB-UHFFFAOYSA-N H-bond Acceptor ： 3 H-bond Donor ：

  2. 1 SP3 ： 0.50 RBN ： 0 Chemical Products N-Hydroxysuccinimide Characteristics Appearance ： Clear yellow-brown to brown Liquid or Solid Density ： 1.6±0.1 g/cm3 Melting Point ： 95-98 °C(lit.) Bolling Point ： 262.4°C at 760 mmHg Flash Point ： 112.5±22.6 °C Refractive Index ： 1.600 Solubility ： H2O: soluble Storage Condition ： 2-8°C BRN ： 113913 Stability ： Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong bases. Protect from moisture. Chemical Products N-Hydroxysuccinimide Safety Information HS Code ： 29251995

  3. UN No. ： NONH for all modes of transport WGK_Germany ： 3 Risk Code ： 36/37/38 Safety Instructions ： 22-24/25-26-36 Dangerous Mark ： Xi P Code ： P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501 Hazard Statements ： H315 Hazard Note ： Irritant Chemical Products N-Hydroxysuccinimide Usage Additive used in the carbodiimide method for improved amidations and peptide couplings.

  4. Chemical Products N-Hydroxysuccinimide Production Methods 100g (1.0mol) of succinic anhydride and 70g (1.0mol) of hydroxylamine hydrochloride were heated together to keep the reaction system under negative pressure to remove the generated volatiles, quickly heated to above 125℃, and slowly raised to 160℃ after 1h. The heating was stopped, and when the temperature dropped to 125°C, the liquid reactant was poured into 400 ml of ether and stirred vigorously. After the product solidified, the ether layer was decanted. The cured product was heated to boiling with 400 ml of butanol, filtered hot, and the filtrate was quickly cooled to 0°C. After 1h, it was filtered, and the crystals were washed with butanol and ether in sequence. The resulting crude product was recrystallized with ethyl acetate to obtain 50g of finished product with a yield of 44%. Chemical Products N-Hydroxysuccinimide Material Acetic acid Hydroxylamine hydrochloride

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