1 / 24

Modelling Impulsivity: adapting rodent gambling task (rGT) for the touchscreen box

Modelling Impulsivity: adapting rodent gambling task (rGT) for the touchscreen box. HaoSheng Sun Mount Sinai School of Medicine. Fractionating Impulsivity. Winstanley et al., 2010. Iowa Gambling Task - IGT.

Download Presentation

Modelling Impulsivity: adapting rodent gambling task (rGT) for the touchscreen box

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Modelling Impulsivity: adapting rodent gambling task (rGT) for the touchscreen box HaoSheng Sun Mount Sinai School of Medicine

  2. Fractionating Impulsivity Winstanley et al., 2010

  3. Iowa Gambling Task - IGT • Pathological gambling is a compulsive and maladaptive activity comparable with drug addiction • May be a component of the multi-faceted behavioural construct of “impulsivity”, which includes impulsive action (motor impulsivity), impulsive choice (small immediate reward versus delayed large reward) etc • Iowa Gambling Task was developed to assess and quantify the decision-making defects of neurological patients by simulating real-life decision in conditions of reward and punishment and of uncertainty The optimal strategy is to chose options leading to smaller immediate gains, but also low and infrequent losses C A D B Bechara et al., 1997 Zeeb et al., 2009

  4. Iowa Gambling Task - IGT Bechara et al., 1997

  5. Impairments on the IGT • Increases in risky decision-making on the IGT are also seen in patients with: • Pathological Gambling (PG) • Substance Abuse Disorder • Parkinson’s Disease patients receiving DA agonist therapy (only a subpopulation) • OCD • Depression

  6. Rat Gambling Task - rGT

  7. Rat Gambling Task - rGT • 30 min to “gamble” Food Tray Adapted from Fiona Zeeb

  8. Rat Gambling Task - rGT • 30 min to “gamble” Food Tray Adapted from Fiona Zeeb

  9. Rat Gambling Task - rGT • 30 min to “gamble”     5 sec 5 sec 5 sec 5 sec Premature Premature Premature Food Tray Adapted from Fiona Zeeb

  10. Rat Gambling Task - rGT • 30 min to “gamble” Food Tray Adapted from Fiona Zeeb

  11. Rat Gambling Task - rGT • 30 min to “gamble” Reward 1 4 2 3 Food Tray Adapted from Fiona Zeeb

  12. Rat Gambling Task - rGT • 30 min to “gamble” Reward 1 4 2 3 WIN  Food Tray Adapted from Fiona Zeeb

  13. Rat Gambling Task - rGT • 30 min to “gamble” Reward 1 4 2 3 Time-Out 5 40 10 30 LOSS  Food Tray Adapted from Fiona Zeeb

  14. Rat Gambling Task - rGT Zeeb et al., 2009

  15. Rat Gambling Task - rGT Zeeb et al., 2009

  16. Rat Gambling Task - rGT Zeeb et al., 2009

  17. Touch Screen Operant Box

  18. rGT Training Stage 1 Pre-training Train rats up to criterion (>50 trials in 30 minutes, >80% accuracy, <20% omission) in adapted 4CSRTT with 10 s limited hold and 10 s stimulus durtaion. Stage 2 Forced choice training Present each pellet option (with associated probability of reward and punishment duration) one at a time. 7 sessions. 2 variation of task (VarA: 1 4 2 3 VarB: 4 1 3 2 Stage 3 Free choice training As shown in previous schematics. Continue as same variation of task as before ~30 sessions until stable choice forms

  19. rGT Training Sun, unpublished data Zeeb et al., 2009

  20. rGT Training Version A: 1 4 2 3 Version B: 4 1 3 2 ?? Sun, Zeeb unpublished data

  21. Future Direction • Further validate rGT task in touchscreen boxes • Run animals until stable choice behaviour forms • Validate effect of acute drug treatment on drug behaviour • If difference in baseline behaviour persist, investigate reason for differences (ie housing condition etc) • Effect of viral overexpression of CREB on gambling choice behaviour

  22. CREB and impulsive behaviour Sun et al., 2010

  23. CREB and impulsive behaviour Investigate whether CREB in the OFC affects other constructs of impulsivity? Ie in the gambling task Sun et al., 2010

  24. Acklowdgement Dr.Mark Baxter Dr.Catharine Winstanley Fiona Zeeb And the gambling rats! Terry Echard

More Related