Structure Function and Evolution of the Graham Cromar and Dr. John Parkinson Program in Molecular Structure and Function Hospital for Sick Children Toronto, ON, CANADA Extracellular matrix Committee Members: Dr. Johanna Rommens Dr. Andrew Emili Dr. Gary Bader In the lab: Dr. Jose Peregrin-Alvarez, Dr. James Wasmuth, Chris Sanford, David He
Aims Map known disease genes onto the functional map to understand how the ECM is involved in health and disease.
GO Cellular Component = ECM Biological Process Molecular Function Gene Ontology Methods Protein Databases Uniprot RefSeq Ensembl Filter Render Interaction Databases DIP BioGRID Database of ECM proteins IntAct Search Mint
The network was constructed, then expanded using orthologues 613 Human Mouse 28 4 354 190 Human Mouse 807 1611 166 1267 Rat 463 69 69 Rat Mouse – 2268 Rat – 1910 Human - 1165 Human - 2252
Interesting biological results? 8,3,1,2,4 18,12 14,8,17,25 5,7,6,9 5,6,11,12,23