Most Visionary Executives Driving Innovation in Healthcare

1. Decisive Action in Critical Moments THE IMPORTANCE OF LEADERSHIP IN HEALTHCARE CRISIS MANAGEMENT MOST VISIONARY Driving Innovation in Shifting from Treatment to Prevention THE IMPORTANCE OF PREVENTIVE HEALTHCARE , , The best way to predict the future of healthcare is Cover Feature to innovate , , it today. JESSE BETHKE GOMEZ P I O N E E R I N G E X C E L L E N C E I N H E A L T H C A R E I N N O V A T I O N

2. I S T H E H I G H E S T F O R M O F H E A L T H .

3. I S T H E H I G H E S T F O R M O F H E A L T H .

4. Spotlighting the Guardians of Collective Well-being ealthcare has always been more than a profession—it is a H steady hands of nurses during the night's loneliest hours, the keen minds of researchers pushing the boundaries of science. These individuals are not merely professionals; they are the guardians of our collective well- being, the ones we trust in moments of vulnerability. Their work is not measured in profits or accolades but in lives saved, in comfort given, in hope restored. calling, a commitment to alleviating suffering and preserving life. It is the quiet courage of surgeons in operating rooms, the This edition brings together the visionaries reshaping healthcare through bold leadership and transformative innovation. These executives are not only responding to challenges but redefining what is possible—expanding access, harnessing technology, and building systems that prioritize human dignity. From groundbreaking medical advancements to smarter healthcare delivery, they are setting new standards, ensuring that care is not just available but exceptional. The urgency of highlighting these leaders stems from more than admiration; it is a necessity. Healthcare is undergoing a profound shift, where decisions made today will shape the wellness of generations to come. These individuals stand at the intersection of medicine, technology, and policy, ensuring that innovation serves not just efficiency but humanity. , , The future of healthcare holds extraordinary promise—diseases that once seemed insurmountable are being met with groundbreaking treatments, and digital advancements are making care more precise, personal, and accessible. The leaders featured in this edition are at the forefront of this evolution, crafting a healthcare landscape where science and compassion walk hand in hand. As they continue to push the limits of what can be achieved, one truth remains clear: the best days of healthcare are still ahead of us. Innovation in healthcare is not about fixing broken things, it's about creating something better. - Elizabeth Holmes , , - Kevin Smith Managing Editor

5. PUBLISHER: WORLD CARE MAGAZINE Managing Editor Kevin Smith Art and Design Head Nicole Wilson Business Development Jack Miller, Michael Brown, Executives Melissa Anderson, Ashley Thompson Marketing Manager Grace Jackson Technical Head Luca Ferrari Digital Marketing Manager Sophia Rossi Circulation manager Henry Scott Accounts Alexander Marinov Contact Us: Michael Brown michael@worldcaremagazine.com Whatsapp: +44 20 4577 4296 / +1 307 314 1238

6. WHAT’S INSIDE C N T E N T S 06 O 24 18 C O V E R S T O R Y P R O F I L E P R O F I L E

7. ! WHAT’S INSIDE C O N T E N T S 14 32 A R T I C L E A R T I C L E

8. CO S T V E R R Y JESSE BETHKE GOMEZ Crafting a Legacy of Dignity in Direct Care Our vision for the future isn't just about expanding our physical space—it's about creating a heartfelt invitation of welcome, belonging where individuals with disabilities can thrive, connect, and lead. , , , , www.worldcaremagazine.com 06

9. METROPOLITAN CENTER FOR INDEPENDENT LIVING www.worldcaremagazine.com 07

10. Across the United States, a silent crisis is unfolding—one that doesn't make daily headlines but is reshaping lives in irreversible ways. The shortage of direct care workers has reached catastrophic levels, forcing individuals who rely on them out of their homes and into institutions, unraveling the very fabric of independence and dignity. This isn't just about numbers or statistics; it's about real people—about a nation unprepared for the tidal wave of aging populations and the growing demand for home-based care. the American Red Cross when he worked at American Red Cross. The presidential scholarship award allowed Jesse to become a graduate of the Minnesota Executive Program for Advanced Strategic Leadership from the Curtiss L. Carlson School of Management at the University of Minnesota. Jesse also is a national Kellogg Fellow that allowed him to attend the #1 public health school in the nation at the University of North Carolina Chapel Hill, along with the University's business school that co- presented advanced public health leadership. As a CEO in his current leadership role with MCIL, this is his third successive corporation he has led to greater performance and results. He has raised over $60 million in his fundraising efforts thus far in his career. While most see this crisis as insurmountable, Jesse Bethke Gomez sees it as a call to action. Where others offer temporary fixes, he envisions systemic change. His groundbreaking work as Executive Director of the Metropolitan Center for Independent Living (MCIL) is not just about closing the workforce gap—it's about redefining the role of direct care in society, elevating it to the status it deserves, and ensuring that those who dedicate their lives to caregiving are recognized, respected, and rewarded. Today as Executive Director of MCIL, Jesse leads a wide range of programs and services that focus upon assisting people with disabilities to overcome barriers toward greater independent living. Over the past two years, MCIL has directly reached more than 13,534 people while also engaging with an additional 54,894 unique clients resulting in a total of 171,826 contacts through Disability Hub MN™, a statewide call center in which MCIL along with Southeastern Center for Independent Living both serve for over 20 years thus far, as operations centers for the Hub in working with the Disability Services Division of the Engineering a Future of Independence and Care Jesse Bethke Gomez brings to his leadership role a Master of Management and Administration degree with an emphasis on strategic leadership. Jesse is a recipient of a national Presidential Scholarship award from Elizabeth M. Dole, CEO of www.worldcaremagazine.com 08

11. Minnesota Department of Human Services. Minnesota Foundation, the Minnesota Legislature, and the Disability Services Division of the Minnesota Department of Human Services. average of 10 hours per week to support individuals who rely on PCA assistance for daily living. While participants are employed by a PCA agency, MCIL provides mentoring and a financial incentive. The program also recruits individuals who are assessed at 10 or more hours of PCA assistance per day and who direct their own care , , With over 650,000 people with disabilities in Minnesota—50% of whom reside in the seven-county St. Paul and Minneapolis region—MCIL is deeply committed to its mission statement—To advance the independent living of people with disabilities by Removing Barriers and Promoting Choices. As a Center for Independent Living, more than half of MCIL's Board of Directors and 65% of its 77 staff members are individuals with disabilities, ensuring that the organization remains genuinely connected to the community it serves. The second major initiative, funded by The Bush Foundation, has focused on developing a curriculum leading to the credential of "Certified Direct Support Professional." Unlike the medical sector, which has long recognized the role of a Certified Nursing Assistant, the home care sector has lacked a similar educational pathway toward a postsecondary credentialed role. Jesse and his team have collaborated with college faculty to create a curriculum that not only establishes this certification but also ties it to a competitive wage differential across direct care services. Additionally, MCIL is working closely with Minnesota's postsecondary institutions and state agencies in planning to implement this educational opportunity, ensuring long-term workforce sustainability. At MCIL, we're advocating for independence, dignity, and systemic change. Every individual we help transition from institutional care to independent living is a victory for the inalienable rights and dignity of humanity. Since its establishment in 1981, MCIL has continuously gathered input from the disability community to shape its priorities. In 2015, when Jesse assumed leadership, prominent disability community leaders urged him to address Minnesota's severe direct care workforce shortage crisis. In response, he joined a state direct care workforce committee alongside an MCIL representative and contributed as a technical writer for a high-level recommendations report approved by the Minnesota government. This report guided MCIL's focus on developing formalized education for direct care workers and creating new pathways to attract job seekers to the field. Through these initiatives, Jesse and MCIL are making significant strides in strengthening the direct care workforce, improving career pathways, and enhancing the quality of care for individuals with disabilities across Minnesota. Dismantling Barriers to Independence and Empowerment Strides to Strengthen Direct Care Workforce As the Executive Director, Jesse leads the organization in its mission to advance independent living for people with disabilities by removing barriers and promoting choices. Under his leadership, MCIL is now in its second year of its approved five-year strategic plan, titled To Advance the Independent Living of People with Disabilities by Removing Barriers and Promoting Choices. With a renewed focus on mission, meaning, and the power of Under Jesse's leadership, MCIL has pioneered two groundbreaking solutions to address the direct care workforce crisis. The first initiative, the PCA College Service Corps, is a pilot program designed to attract college students to work as Personal Care Assistants (PCAs). Through this program, students commit to a 30- week service period, working an and are authorized to receive Minnesota's direct care services. This initiative has gained significant support from post-secondary institutions, recognizing higher education's role in addressing the workforce shortage. The program is made possible through funding from the Margaret A. Cargill Foundation Fund of the St. Paul and , , www.worldcaremagazine.com 09

12. independent living, the organization remains dedicated to ensuring that individuals with disabilities can fully embrace their inalienable rights, human dignity, and pursuit of happiness within vibrant communities. board members who are deeply committed to civil rights, Americans with Disabilities Act, accessibility, and ensuring that people with disabilities have the necessary support to live independently. His extensive experience, having served on more than 42 boards and commissions throughout his career, and as a CEO over many corporations, informs his leadership in aligning MCIL's strategic direction with its mission. The organization maintains a structured planning process that includes service development, human resources strategies, financial operating budgets, and board engagement, all of which ensure a steadfast focus on delivering mandated services while expanding initiatives that enhance independent living. The 2024 strategic plan reflects a deep commitment to civil rights, recognizing the historic role of the Civil Rights Act in establishing as law, protected classes of populations from discrimination, including individuals with disabilities, and the Americans with Disabilities Act The plan also underscores the responsibility of MCIL to further advance accessibility, person-centered responsiveness, belonging, and stabilizing people, and their families in community, thus building vibrant communities that in turn results in economic sustainability. , , Through MCIL's Transitional Services Program, we've helped thousands of people move out of institutions and into homes of their own. The cost savings to the system are enormous, but the real impact is in the lives changed for the better. , , With a staff of 77 professionals, Jesse cultivates a culture of dedication and excellence by embedding MCIL's core values into every aspect of its operations. These values include Human Dignity, affirming that all individuals, possess inherent worth. Mindfulness and Responsiveness guide the organization's empathetic and attentive approach to assisting individuals in leading self-determined lives. The principles of Self- Empowerment and Self-Determination emphasize that people with disabilities are the best experts on their own needs, deserving equal opportunities to shape their own lives of independent living and communities. Jesse has ensured that MCIL remains strategic and intentional in utilizing its thought leadership to address critical issues, including the direct care workforce crisis, which poses a significant challenge to human dignity and independent living for individuals, families, and youth with disabilities. At its core, MCIL envisions a society that upholds its commitment to civil rights, accessibility, welcome, belonging, self- determination, human dignity and independent living for all. This vision is captured in the statement: We believe in a world of opportunities, choices, and the freedom to live those choices, with dignity. A rigorous strategic plan, coupled with comprehensive program evaluations, allows the organization to measure and report on its impact annually. MCIL's commitment to fostering a welcoming, accessible and supportive workplace of belonging, is reflected in its strategic human resources plan, which includes an independent annual employee survey. Notably, 100% of employee respondents identify with MCIL's mission, demonstrating the organization's dedication to creating an environment where every team A Guardian of Dignity A key aspect of long-term sustainability at MCIL is the collaboration with its Board of Directors. Jesse works closely with www.worldcaremagazine.com 10

13. member feels valued and motivated to further the cause of independent living. Jesse credits his mentor whom he personally trained with early in his career, W. Edwards Deming, Ph.D. who created the quality improvement movement globally, on the value of "driving fear out of the workplace" where all are appreciated, valued and belong. services to someone who was able to not only receive assistance with their damage deposit and moving services but was also able to pick out a new couch of their choice after never having owned a new piece of furniture before!” MCIL is honored to serve as the home for ADA Minnesota Program. Jesse underscored MCIL's commitment to advocating for policy changes that further the rights and independence of individuals with disabilities. He acknowledged the Civil Rights Act's historic role in recognizing people with disabilities as a protected class, along with the American with Disabilities Act, emphasize that MCIL's mission aligns with advancing human dignity, person-centered responsiveness, and the development of accessible, vibrant communities that contribute to regional economic sustainability. Over the past two years, MCIL's Transitional Services Program has assisted 1,633 individuals from transitioning from institutional settings into the community. Jesse pointed out that the long-term care costs associated with these individuals represent an estimated annual savings of $104,839,000 to $250,945,000. This calculation is based on the annual cost of a nursing home stay in Minnesota, which averages $153,665, compared to $64,200 for an assisted living facility, according to Genworth CareScout 2023 data. Through strategic planning, strong governance, and a deeply embedded values-driven culture, Jesse continues to guide MCIL toward meaningful change, ensuring that individuals with disabilities receive the support and resources necessary to live independently and with dignity. Jesse detailed MCIL's advocacy efforts, which focus on ensuring compliance with federal laws that protect the rights of individuals with disabilities. Key legislation includes the Americans with Disabilities Act (ADA), particularly Title II, which mandates accessibility in all healthcare and social service programs operated by public entities. Additionally, Section 504 of the Rehabilitation Act of 1973 requires non-discriminatory access to programs and services receiving federal financial assistance, while Section 508 ensures accessibility for electronic and information technology provided by the U.S. Department of Health and Human Services, and the Workforce Innovation and Opportunity Act, which as federal legislation, has the statutory language on the role of the Centers for Independent Living and Statewide Independent Living Councils. The Architect of Independent Futures Managing a $8.1 million budget across a broad scope of services requires a strategic approach to resource allocation. Jesse explained that the Metropolitan Center for Independent Living (MCIL) ensures efficiency by aligning services with the organization's leadership structure and cost centers, optimizing impact while maintaining fiscal responsibility. Advancing Human Dignity and Person-Centered Responsiveness MCIL operates in collaboration with statewide entities such as the Minnesota Association of Centers for Independent Living. Jesse noted that MCIL is one of 408 Centers for Independent Living nationwide and operates under the Centers for Independent Living Rules and Regulations of the Workforce Innovation and Opportunity Act (45 CFR Part 1329, November 28, 2016) and Minnesota State Statute (268A.11 Subdivision 8). As one of eight Centers for Independent Living in Minnesota, MCIL works alongside its counterparts and with the Minnesota Statewide Independent Living Council (MNSILC) to advance independent living throughout the state. Jesse emphasized that these partnerships are essential for ensuring a coordinated approach to supporting individuals with disabilities. MCIL is committed to assisting people with disabilities in transitioning from long-term institutional settings to accessible settings in the community in advancing independent living. Jesse shared a success story from MCIL's Transitional Services housing advocacy efforts, illustrating the organization's impact; "Moving to a new home can be an expensive and arduous process – application fees, deposits and moving services are incredibly expensive and often unattainable, many times leaving individuals feeling stuck in their current living situations. Recently, MCIL provided transitional housing Contributing to a Vibrant and Inclusive Community Looking to the future, Jesse shared MCIL's plans for a renovation and expansion of its headquarters in downtown St. Paul, Minnesota. The expansion aims to provide additional space for employees and services while www.worldcaremagazine.com 11

14. inviting additional agencies who also assist people with disabilities and policy-focused institutions to co-locate within the facility. Jesse described the vision for the new space as a welcoming environment designed with universal accessibility in mind, where individuals with both apparent and non-apparent disabilities can access services, build social connections, and contribute to a vibrant community of belonging. Pioneering a Compassionate Workforce and Societal Transformation Jesse emphasized the severity of the direct care workforce shortage crisis across the United States, noting that individuals who rely on direct care workers for daily living are facing an escalating gap in available support. This shortage has led to dire consequences, including people being forced out of their homes and experiencing unaddressed health complications. To address this growing crisis, Jesse advocates for a transformative macro strategy that introduces a new model and a credentialed role of a Certified Direct Support Professional. He asserts that this new role must be fully integrated into all aspects of society, including the federal government and all 50 states. Jesse stresses that Congress must recognize the critical importance of the direct care workforce and ensure that the homecare sector receives equal attention alongside the medical sector, as both are integral components of the nation's healthcare system. He highlights the demographic shift currently taking place, noting that today's older adult population is larger than in the past three to four decades combined and is projected to peak www.worldcaremagazine.com 12

15. around the 2050s. Jesse underscores the importance of recognizing today's historic moments to solve the direct care crisis, and seizing opportunities to implement solutions that transform society in positively impact future generations. play a significant role in upholding this fundamental principle. He urges society to reflect on the shared human experience, emphasizing that our human nature is the same for all, and we all undergo the universal journey of life. In envisioning a solution, Jesse imagines a future where over four million direct care workers in the United States pursue and attain the credential of a Certified Direct Support Professional, receiving competitive wages and contributing to a sustainable workforce. Imagine also post- secondary institutions throughout the United States of America inviting college students to participate in the PCA College Service Corps in advancing their career success, increasing their awareness about the support needed to assist people who rely upon direct care services for daily living and greater civic participation in addressing the direct care crisis. He envisions a society where people with disabilities and older adults have reliable access to direct care services, leading to stronger, more vibrant communities that lead to economic sustainability and greater care for one another. Jesse calls upon leaders in healthcare, higher education, workforce development, elected officials, and governors across all 50 states to champion solutions to solve the direct care crisis including the Certified Direct Support Professional model and the PCA College Service Corps. He believes that establishing this credential role will not only contribute to resolving the workforce crisis but also enable individuals in long-term institutional care settings to return home. Additionally, he envisions that strengthening the direct care workforce will lead to more vibrant communities and contribute to regional and national economic sustainability. , , Jesse underscores the importance of recognizing today's historic moments to solve the direct care crisis, and seizing opportunities to implement solutions that transform society in positively impact future generations. , , To further his efforts, Jesse has initiated discussions with the Federal Reserve Bank regarding their ongoing assessments of the economic impact of the direct care workforce crisis. He has also engaged with global stakeholders who are interested in adopting this transformative framework to address similar challenges in their own countries. Recognizing the widespread nature of this crisis, Jesse expresses his intention to bring the issue before the United Nations to elevate the need for a worldwide solution, emphasizing that humanity has both the resolve and the power to act to transform our world. Rather than questioning why such an initiative should be pursued, Jesse challenges others to ask: Why not? Jesse remains hopeful that the direct care workforce shortage crisis can be solved through collective action. He asserts that one of civilization's most noble values is to advance the ability of people to care for one another, and he believes that healthcare leaders can www.worldcaremagazine.com 13

16. THE IMPORTANCE OF Leadership IN HEALTHCARE CRISIS MANAGEMENT www.worldcaremagazine.com 14

17. Decisive Action in Critical Moments H implemented lockdowns, testing, and vaccination programs saw lower fatality rates. In contrast, indecisive leadership resulted in overwhelmed hospitals and higher mortality. ealthcare crises, whether caused by pandemics, natural disasters, cyberattacks, or resource shortages, test the resilience of healthcare systems worldwide. In such times, strong leadership is not just beneficial—it is essential. Effective healthcare crisis management relies on decisive action, clear communication, and strategic problem-solving. Leaders in healthcare, from hospital administrators to public health officials, play a crucial role in mitigating crises, ensuring patient safety, and maintaining public trust. 2. Clear and Transparent Communication Misinformation can spread rapidly during healthcare crises, leading to public fear and non-compliance with safety measures. Strong leaders provide accurate, timely, and transparent communication to both healthcare workers and the public. The Role of Leadership in Healthcare Crises Good crisis communication involves: • Providing regular updates to healthcare staff and the public. Using multiple communication channels (press briefings, social media, official reports). Addressing misinformation swiftly and ensuring clarity. Leadership in healthcare crisis management involves guiding teams, making high-stakes decisions, and responding swiftly to evolving challenges. Key aspects of effective leadership during a crisis include: • • 1. Rapid Decision-Making In healthcare crises, time is a critical factor. Delayed responses can lead to preventable deaths, system overload, and public panic. Effective leaders assess situations quickly, rely on data- driven insights, and make informed decisions under pressure. For example, during the COVID-19 pandemic, countries with proactive healthcare leaders who swiftly For instance, during the Ebola outbreak, the World Health Organization (WHO) and local health leaders played a crucial role in educating the public about symptoms, prevention, and containment measures, which helped control the spread. www.worldcaremagazine.com 15

18. 3. Ensuring Resource Allocation and System Preparedness ensure a sustainable workforce during prolonged crises. • Political and Bureaucratic Barriers: Slow governmental responses and red tape can delay critical actions. Public Distrust: In some cases, past failures erode trust, making it harder for leaders to implement safety measures. Resource Limitations: Low- income regions often struggle with inadequate healthcare infrastructure and funding. Overcoming these challenges requires a commitment to transparency, proactive planning, and investment in healthcare resilience. One of the biggest challenges in healthcare crises is the strain on resources—hospital beds, ventilators, medications, and staff. Strong leadership ensures that resources are distributed efficiently and equitably. 5. Collaboration and Coordination • No single entity can manage a healthcare crisis alone. Effective leaders foster collaboration among government agencies, private healthcare providers, research institutions, and international organizations. • Successful crisis leaders: • Monitor resource levels and anticipate shortages. Coordinate with governments, private sector partners, and international organizations for support. Implement contingency plans, such as setting up emergency field hospitals or reallocating medical personnel. • For example, global cooperation during the COVID-19 crisis led to the rapid development of vaccines through initiatives like COVAX. Leaders who facilitated partnerships between scientists, pharmaceutical companies, and healthcare institutions accelerated vaccine distribution. • • Conclusion Leadership in healthcare crisis management is crucial in minimizing harm, protecting healthcare workers, and ensuring effective responses. Strong leaders must act decisively, communicate transparently, allocate resources efficiently, and foster collaboration. As future healthcare challenges emerge, investing in leadership training and crisis preparedness will be essential for safeguarding public health. 6. Adapting to Evolving Challenges During the COVID-19 pandemic, some healthcare leaders successfully scaled up hospital capacities and coordinated the supply chain for medical equipment, preventing catastrophic shortages. Crises are unpredictable and require leaders to remain flexible and adaptive. A good healthcare leader: • Monitors emerging threats and adjusts strategies accordingly. Learns from past mistakes and implements corrective measures. Encourages innovation in treatment protocols, logistics, and digital healthcare solutions. 4. Supporting and Protecting Healthcare Workers • • Healthcare professionals are at the frontlines during crises, often working long hours under immense stress. Leaders must ensure their well-being, both physically and mentally. During the SARS outbreak, Singapore's healthcare leaders adapted quickly by integrating digital contact tracing and refining quarantine strategies, which helped contain the virus efficiently. Effective leadership includes: • Providing personal protective equipment (PPE) and ensuring workplace safety. Offering mental health support and crisis counseling. Implementing fair work schedules to prevent burnout. Leaders who prioritize their teams' well-being foster resilience and Challenges in Healthcare Crisis Leadership • While effective leadership can improve crisis outcomes, several challenges exist: • • www.worldcaremagazine.com 16

19. www.worldcaremagazine.com 17

20. www.worldcaremagazine.com 18

21. www.worldcaremagazine.com 19

22. www.worldcaremagazine.com 20

23. www.worldcaremagazine.com 21

24. Visit terrake.fr to learn more.

25. in Every Swipe Con?dence Experience the magic of Terraké France and let your beauty speak for itself.

26. Kuldip Sidhu Execu?ve Director & Chief Scien?fic Officer CK Cell Technologies Pty Ltd www.worldcaremagazine.com 24

27. Kuldip Sidhu Rede?ning Healthcare Standards Through Innovation T promise for transformative breakthroughs in addressing various human health conditions. Innovations in stem cell science pave the way for novel therapeutic modalities, aiming to tackle challenges ranging from spinal cord injuries to skin rejuvenation. This industry's focus on harnessing the potential of stem cell-derived products as exosomes underscores a commitment to enhancing human well- being through cutting-edge research and development. he landscape of advanced science in the realm of regenerative medicine holds Guiding CK Cell Technologies' visionary endeavors is an esteemed executive who has contributed significantly to the field of regenerative medicine. Under the leadership of Executive Director & Chief Scientific OfficerProf Kuldip Sidhu, the company charts a course toward addressing unmet medical needs with a focus on conditions such as Alzheimer's disease, spinal cord injuries, Diabetic Foot Ulcer (DFU), and COVID-19-ARDS(acute respiratory distress syndrome)-related complications. With a wealth of expertise and a commitment to advancing therapeutic solutions, Prof Kuldip Sidhu spearheads CK Cell Technologies' mission to redefine the standards of healthcare delivery through innovation and collaboration. CK Cell Technologies emerges as a notable player within this dynamic industry, positioning itself at the forefront of pioneering advancements in stem cell therapeutics. As a dedicated research and development (R&D) division operating under a larger corporate entity(Clairevale Pty Ltd), CK Cell Technologies leverages state-of-the-art facilities and groundbreaking technologies to drive innovation forward. Situated within the esteemed Norwest Business Park in NSW, Australia, the company's commitment to excellence is evident through its accreditation and adherence to stringent regulatory standards. Let's move ahead with this exceptional story: Advancing Stem Cell Science for Human Health The vision at CK Cell Technologies is centered around the advancement of the innovative science of stem cell- derived products (exosomes) as a non- cellular modality aiming to serve as therapeutic strategy for various www.worldcaremagazine.com 25

28. human conditions such as spinal cord injury, wound healing, Alzheimer's, COVID-19 ARDS, DFU, and skin rejuvenation. The company is dedicated to ensuring the quality and safety of its products by consistently implementing and enhancing best practices and adhering to evolving regulatory frameworks. The team's overarching vision is to propel the Australian regenerative market onto the global stage, prioritizing patient needs and fostering strong relationships with researchers and collaborators. Prof Sidhu, as documented in a joint publication in Nature Biotech, CK Cell Technologies is focused on producing evidence-based therapeutic products. lines, the company manages the production, quality control, and scaling of induced mesenchymal stem cells (iMSC) and exosomes internally. Holding five intellectual properties (with patents pending), one of which has reached the national phase, CK Cell Technologies is deeply engaged in advancing this technology. Their flagship product, Endexome- TM EXO , consists of exosomes derived from induced mesenchymal stem cells (iMSC) generated from human iPSC via a patented technology, ensuring a consistent supply of materials with minimal batch-to-batch variations. TM Endexome-EXO is fully compliant with international regulatory standards and thoroughly characterized for quality, efficacy, and scalability. Notably, CK Cell Technologies stands among the select few globally to possess clinical pilot trial data attached to this product, demonstrating its safety and efficacy without any adverse events reported. With approvals obtained for its international distribution of non-clinical applications, the company is poised to advance its presence both locally and overseas. Human pilot trials, including Phase I/II studies, have been successfully conducted for conditions such as COVID-19 ARDS, Diabetic Foot Ulcer (DFU), and Spinal Cord Injury, with a specific focus on skin rejuvenation. Notably, the skin rejuvenation product TM Endexome-EXO has received approval for international distribution, supported by comprehensive clinical data. Expanding its clinical applications, the company utilizes this product for ongoing development in various medical areas of need, facilitated through its clean room facility in collaboration with other stakeholders. In pursuit of this vision, CK Cell Technologies has set forth several missions. They aim to establish themselves as leaders in the development of stem-cell-based diagnostic and therapeutic discoveries, with the goal of transforming human health through regenerative medicine. This mission will be accomplished through collaborative efforts involving scientists, clinicians, technicians, and health workers working synergistically under one roof. Advancing Therapeutic Solutions Driving Innovation Pioneering Stem Cell Therapeutics The immediate focus of CK Cell Technologies, under Prof Kuldip Sidhu's direction, lies in addressing areas of human health characterized by a lack of definitive treatments, relying solely on symptomatic management. These areas include Alzheimer's disease, Spinal Cord Injury, COVID-19 ARDS (long COVID), Diabetic Foot Ulcer, Surgical wounds, and skin rejuvenation. The therapeutic pipeline for these conditions spans from laboratory trials to human pilot trials, with progressive advancement toward Phase I/II clinical trials. With over 40 years of experience in the field, Professor Kuldip Sidhu has amassed a wealth of expertise, evidenced by extensive publications comprising two books and over 200 research papers. Concurrently, he has held a cojoint position with the Faculty of Medicine at the University of New South Wales, Australia, for more than 25 years. Prof. Sidhu has been instrumental in developing both national and international consortia in the realm of regenerative medicine. CK Cell Technologies, as part of a corporate entity comprising Clairevale Pty Ltd as its holding company and Endexome Pty Ltd as its commercial arm, operates as a dedicated research and development (R&D) division. Situated within the Norwest Business Park in NSW, Australia, the company boasts a cutting-edge facility accredited for R&D activities by NATA (National Association of Testing Authority Australia) and holds registration with the FDA for cosmeceuticals. Utilizing Nobel Laureates' Technology pioneered by Prof Shinya Yamanaka, specifically induced pluripotent cells (iPSC) technology, which was collaboratively shared for stem cell quality initiative during a seven-year tenure within an international consortium alongside CK Cell Technologies has established legal agreements with various esteemed institutions, including universities such as UNSW, UOW, UWS, UTS, and MQU, as well as institutes like NATA, CCRM, ACTA, and NSW Biobank. Additionally, the company is a participant in national consortia initiatives such as the 'Smart CRC,' which is currently under Advancing Exosome Technology The company, led by Prof Kuldip Sidhu, is at the forefront of pioneering cell-free exosome-based therapeutics, leveraging iPSC technology developed by a Nobel Laureate. With a dedicated biobank housing proprietary iPSC www.worldcaremagazine.com 26

29. Our therapeutic pipeline spans from laboratory trials to human pilot trials, with progressive advancement towards Phase I/II clinical trials , , www.worldcaremagazine.com 27

30. CK Cell Technologies stands among the select few globally to possess clinical pilot trial data demonstrating the safety and efficacy of their product , , www.worldcaremagazine.com 28

31. development. Strong support from the Commonwealth Government of Australia bolsters the company's R&D endeavors, complemented by a dedicated base of loyal investors. An international trade agreement with India has been solidified through the operational activities of the company's subsidiary there. The Science Advisory Committee, comprising scientific, medical, and clinical directors, plays a pivotal role in guiding the clinical translation efforts. Furthermore, CK Cell Technologies boasts a board of management with clearly defined mandates for science, clinical, and marketing portfolios, ensuring strategic alignment and effective governance. Advanced Therapies & Innovations CK Cell Technologies is at the forefront of pioneering stem cell-based diagnostics for Alzheimer's disease (AD) by leveraging innovative techniques to create mini-brains in vitro. This approach aims to replicate conditions seen in AD patients, allowing for the assessment of the disease's progression in a matter of weeks rather than the typical 10-15- year latency period observed in humans. human embryonic stem cell line, known as Endeavour-1, in collaboration with comprehensive characterization and international patenting, facilitating wider distribution through NIH channels. masks, and microneedling, all of which are nearing completion for marketing. Advancements in iPSC Technology The establishment of CK Cell Technologies stemmed from the pioneering work in iPSC technology led by Prof. Kuldip Sidhu, originally developed by Nobel Laureate Prof. Shinya Yamanaka. Prof. Sidhu's laboratory has successfully generated multiple iPSC lines derived from both sporadic and familial cases of Alzheimer's disease (AD). Building upon this foundation, the company has developed the second generation of iPSC lines, representing a significant advancement in clinical translation. These lines are non-integrating, xeno- free, serum-free, and feeder-free, ensuring compatibility and safety for clinical applications. The company is actively engaged in developing a nasal delivery mechanism for its product, Endexome-EXO , targeting both COVID-19 ARDS and AD patients. Pre-clinical animal trials are underway to evaluate the efficacy of this novel delivery method. The iPSC technology utilized by CK Cell Technologies enables the production of iMSC for the generation of exosomes, serving as an inexhaustible source of material with minimal batch-to-batch variations. The company maintains a biobank housing several such lines, catering to both research and commercial endeavors. TM In the realm of surgical wound care, CK Cell Technologies is advancing the development of a 3D bandage embedded with printed exosomes. This innovative approach enables a slow and sustained release of therapeutic agents, facilitating prolonged & continuous healing for challenging wounds. Additionally, the company's portfolio includes various skin rejuvenation modalities such as creams, serums, face Additionally, Prof. Sidhu's contributions include the creation of the www.worldcaremagazine.com 29

32. www.worldcaremagazine.com

33. , , A STARTS FROM - Robert Urich

34. Shifting from Treatment to Prevention www.worldcaremagazine.com 32

35. The Importance of Preventive Healthcare H ealthcare has traditionally been centered around treating diseases after they occur. However, a growing body of research and real-world evidence supports a shift toward preventive healthcare—proactively addressing health risks before they become serious issues. Preventive healthcare not only improves individual well-being but also reduces the burden on healthcare systems and contributes to a healthier society. healthy eating, and exercise. Secondary Prevention – Early detection strategies like screenings and regular check-ups to identify diseases in their initial stages. Tertiary Prevention – Efforts to manage and slow the progression of existing diseases, such as rehabilitation programs and chronic disease management. • • The Benefits of Preventive Healthcare Understanding Preventive Healthcare 1. Reducing Healthcare Costs Preventive healthcare significantly reduces medical expenses by avoiding costly treatments for advanced diseases. Chronic conditions such as diabetes, heart disease, and cancer are among the leading causes of death and healthcare expenditures worldwide. By investing in early detection and lifestyle modifications, governments and individuals can cut down on the financial burden of these conditions. Preventive healthcare refers to medical practices that focus on disease prevention rather than treatment. It includes routine check-ups, vaccinations, screenings, healthy lifestyle choices, and early interventions. The goal is to detect potential health problems early or prevent them altogether, reducing the need for costly and intensive treatments in the future. For example, the Centers for Disease Control and Prevention (CDC) estimates that for every dollar spent on childhood vaccinations, society saves over $10 in medical costs. Similarly, managing high blood pressure early can prevent expensive complications Preventive care is typically categorized into three levels: • Primary Prevention – Measures taken to prevent diseases before they occur, such as vaccinations, www.worldcaremagazine.com 33

36. like strokes and heart attacks. hygiene, and early detection in controlling outbreaks. treating diseases rather than preventing them, leading to lower investment in preventive strategies. 2. Improving Quality of Life Diseases like polio, measles, and influenza have been largely controlled due to widespread vaccination campaigns. These preventive measures protect not only individuals but also entire communities, reducing the risk of widespread outbreaks. By prioritizing prevention, individuals can maintain better overall health and avoid the physical and emotional strain associated with chronic illnesses. Conditions such as obesity, hypertension, and respiratory diseases can severely impact daily life, reducing productivity and increasing dependency on medications. The Future of Preventive Healthcare To successfully shift from treatment to prevention, a multi-faceted approach is needed: 5. Promoting Health Equity • Education & Awareness Campaigns – Governments and healthcare organizations must educate individuals on the importance of preventive care through public health campaigns. Incentivizing Healthy Behaviors – Employers, insurance companies, and governments can offer incentives for maintaining a healthy lifestyle, such as lower insurance premiums for individuals who undergo regular check-ups. Stronger Policies & Investments – Increased funding for preventive programs, vaccination initiatives, and early detection screenings can lead to better health outcomes. Technology & Digital Health – Wearable devices, AI-driven diagnostics, and telemedicine can enhance preventive healthcare by providing real-time health monitoring and early intervention strategies. Preventive healthcare helps address health disparities by providing equal access to essential medical services, screenings, and education. Many underprivileged communities suffer from preventable conditions due to lack of access to healthcare, nutritious food, and clean environments. Preventive healthcare encourages a proactive approach to well-being, empowering individuals to take charge of their health through nutrition, exercise, and regular medical check- ups. This approach leads to longer, healthier lives and improved mental and physical well-being. • By investing in preventive programs, governments and organizations can bridge the healthcare gap and ensure that all individuals, regardless of socio- economic status, have the opportunity to lead healthier lives. 3. Reducing the Burden on Healthcare Systems • Overburdened healthcare systems struggle to accommodate the increasing number of patients with chronic diseases. By shifting the focus to prevention, hospitals and clinics can reduce the strain on emergency departments and intensive care units, allowing healthcare professionals to allocate resources more effectively. For example, countries with strong preventive healthcare programs, such as Sweden and Japan, have lower hospital admission rates for preventable conditions, leading to more efficient healthcare systems and better patient outcomes. Challenges in Implementing Preventive Healthcare • Despite its benefits, preventive healthcare faces several challenges: • Lack of Awareness – Many individuals prioritize treatment over prevention due to lack of knowledge about preventive measures. Short-Term Costs – Governments and healthcare providers may hesitate to invest in preventive programs because the benefits take time to manifest. Lifestyle Barriers – Unhealthy habits such as poor diet, smoking, and lack of exercise are deeply ingrained in many societies, making behavior change difficult. Healthcare System Focus on Treatment – Traditional healthcare models focus more on Conclusion • Preventive healthcare is a crucial strategy for improving public health, reducing healthcare costs, and enhancing the quality of life. While challenges remain, a collective effort from governments, healthcare providers, and individuals can create a shift from reactive treatment to proactive prevention. Investing in preventive care today will lead to healthier societies and more sustainable healthcare systems in the future. 4. Controlling the Spread of Infectious Diseases • Vaccination programs, hygiene education, and public health initiatives play a crucial role in preventing the spread of infectious diseases. The COVID-19 pandemic highlighted the importance of proactive health measures such as vaccination, hand • www.worldcaremagazine.com 34

37. www.worldcaremagazine.com 35

38. STAY AHEAD IN HEALTHCARE INNOVATION WITH WORLD CARE MAGAZINE GET FEATURED WITH US Contact Us: Michael Brown Email: michael@worldcaremagazine.com Whatsapp: +44 20 4577 4296 / +1 307 314 1238

39. Follow Us

40. Healthcare Magazine That Heals and Inspires The World Care Magazine is dedicated to exploring cutting-edge innovations, inspiring leadership, and remarkable stories from the world of healthcare. We bring together industry experts, pioneers, and in?uencers who are shaping the future of healthcare. Stay informed, stay inspired, and be part of the transformation. Contact Us: Michael Brown Email: michael@worldcaremagazine.com Whatsapp: +44 20 4577 4296 / +1 307 314 1238