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Ernest T. Andalcio Executive Director, Site Head Informatics Pfizer Global Research & Development April 10, 2003 - PowerPoint PPT Presentation


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Internet2 & Pharma Industry National Priorities for Transforming Healthcare Quality Report - implications for patient safety and internet applications. Ernest T. Andalcio Executive Director, Site Head Informatics Pfizer Global Research & Development April 10, 2003. Intro.

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Internet2 & Pharma IndustryNational Priorities for Transforming Healthcare Quality Report - implications for patient safety and internet applications

Ernest T. Andalcio

Executive Director, Site Head Informatics

Pfizer Global Research & Development

April 10, 2003


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Intro

  • Ernest Andalcio - Executive Director - Ann Arbor Labs

  • With Pfizer for 5 years

    • before that Bristol-Myers Squibb, Johnson & Johnson and Procter & Gamble

  • Responsible for mobilizing the talents of IT staff to identify, design, develop and implement robust technology solutions enabling delivery of scientific excellence, and for promoting best practices, fostering IT knowledge-sharing and exploring innovative new technologies


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Intro

  • Challenges for Pharma Industry

  • Opportunities

  • Share some Learnings


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Topics/Contents

  • Pharmaceutical Industry

    • Challenges

    • Opportunities

    • Learnings


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Pfizer Research & Development

  • Largest privately funded biomedicalresearch organization

    • Seven major research sites

    • 2002 R & D investment of $5.3 billion

  • Count on a few new medicines to reachthe market each year

    • 4 filings planned for 2003

    • Target of 20 filings in next 5 years

  • Mission…”We will be the most consistently productive R&D organization in the industry.”


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Topics/Contents

  • Pharmaceutical Industry

    • Challenges

    • Opportunities

    • Learnings


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Challenges in our Industry

  • Balancing

    • Patient needs

    • Medicine

    • Patents

    • New Regulations

    • Profitability

    • Risk

    • Social responsibility

    • Shareholder expectations


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Clinical Trials Require More Patients

Worldwide Industry Number of Patients per NCE

Source: Parexel Pharmaceutical R&D Statistical Sourcebook 2001; Centerwatch, An Industry in Evolution 2001


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Challenges - the long road to a new medicine & how Internet2solutions could one-day help the process

Registration

Full

Development

Exploratory Development

Discovery


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Poor Absorption

  • Not Sufficiently Selective

Too Long in Body

  • Competition

Adverse Reactions

Side Effects

Unsafe

  • Low Levels in Body

Unstable

Not Effective Enough

Impractical To Make

Challenges -R&D Attrition (why new chemical entities fail)

Most

Compounds

Do Not Become

Medicines


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Pharmaceutical Technology in Action

Gather, analyze and present valuable and timely information to therapeutic project teams for high-priority targets.

Use information to help identify novel, high quality targets that may be pursued by the therapeutic project teams.

  • Data Mining

  • Sequence Analysis

  • Information Storage/Retrieval (Database)

  • Information Presentation


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The Challenge…

  • Biology: The Target

  • Select the disease-related protein

  • Understand its function and role

  • Chemistry: The Compound

  • Optimize the potency

  • Avoid adverse pharmacokinetics

  • Avoid adverse toxic effects


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Topics/Contents

  • Pharmaceutical Industry

    • Challenges

    • Opportunities

    • Learnings


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Opportunities - The Future of Medicine

  • Freedom from heart disease

  • A full, normal life for diabetics

  • Preserving the antibiotic miracle

  • Taking the fear out of cancer

  • Eliminating frailty in the elderly

  • Preventing Alzheimer’s disease


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Opportunities - The Future of Medicine

  • Central Nervous System

  • Diabetes

  • Women’s Health

  • Cardiovascular Disease

  • HIV/AIDs

  • Urogenital

  • Pulmonary

20 new filings in next 5 years


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Opportunities - Pharma Informatics

  • Increase productivity

    • Seek different ways of working to increase the number of medicines that make it to full development annually

    • Enable new business processes: Improve data/information for timely decision-making

  • Leverage Scale

    • Take advantage of Global Capacity

    • Maximize use of Best Practices: Quality and Architecture of systems used


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Topics/Contents

  • Pharmaceutical Industry

    • Challenges

    • Opportunities

    • Learnings


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Learnings - Opportunities for Internet2 to make it happen

  • Due to the nature of our business - research - enabling technologies like Internet2 aid internal global execution of the R&D process

    • E.g. “Flipping through” large, secure files (e.g. x-ray images) to spot changes in size of tumors

  • Pfizer does global R&D, however, due to the nature of our business – highly proprietary – it is a largely secure intranet environment:

    • though we accept information from outside vendors using “safe zones” technologies


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Learnings - Opportunities for Internet2 to make it happen

  • Enabling new business processes

    • Streamlined Discovery & Development processes

    • Improved data/information for more timely (real-time) decision-making (Hi bandwidth human interactions! “Charles Yun”)

      • First-time

      • Better

      • Earlier

  • Enabling Digital Science“David G. Messerschmidt”


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Summary

  • Pharma Industry (Challenges/Opportunities)

  • Pharmaceutical R&D processes

  • Internet2… can enable real-time analysis, dialogue and … “discovery” of new medicines


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QUESTIONS?

Ernest.Andalcio@Pfizer.com