DP Accelerator Hardware. Faster alignment. Smith-Waterman, Gotoh, etc., guarantee the best-scoring alignmentHowever, they are too slow to be practical (except with expensive h/w)Subsequent algorithms attempted to provide approximate solutionsFASTABLAST. FASTA (1988). Acceleration of the Smith-Waterman algorithmIdentify strong diagonals in dotplotsUse exact word hits to find these diagonalsRescore best N diagonals with approximate word hitsTry to join together good diagonalsFor sequence-9439
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