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Uncovering Biological Determinants Modulating Breast Cancer Aggressiveness in African American Women. Daisy D. De León, PhD Breast Cancer Laboratory Center for Health Disparities and Molecular Medicine. Breast Cancer and African American Women
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Uncovering Biological Determinants Modulating Breast Cancer Aggressiveness in African American Women
Daisy D. De León, PhD
Breast Cancer Laboratory
Center for Health Disparities and Molecular Medicine
*Per 100,000, age-adjusted to the 2000 US standard population.
† Hispanic is not mutually exclusive from whites, African Americans, Asian/Pacific Islanders, and American Indians.
Source: Surveillance, Epidemiology, and End Results Program, 1975-2001, Division of Cancer Control and
Population Sciences, National Cancer Institute, 2004.
Is IGF-II associated with the increased mortality rate observed among African American women?
All of these characteristics are associated with IGF-II !!
Mitogenic signal (IGF2)
Metabolic signal (insulin)
Adapted from: LeRoith and Roberts (2003) Cancer Letters 195:127.
Hypothesis: IGF-II levels are higher among African American women with breast cancer as compared to Caucasian women. Thus, IGF-II promotes a more aggressive disease that contributes to the increased mortality observed in this ethnic group.
Design: Analysis of IGF-II and IGF-II related proteins in paired normal/tumor tissues from AA & C breast cancer patients.
A similar analysis was performed in breast cancer cells obtained from AA & C patients.
Materials: BC tissue samples were obtained from the “NCI” supported *Cooperative Human Tissue Network. Cell lines were obtained from ATCC. IRB approved and funded by a grant from the National Center for Minority Health & Health Disparities
“I am myself and my circumstance, and if I do not save it, I do not save myself.”José Ortega y Gasset, (1883-1955), Spanish writer, philosopher and revolutionary
Funded by The National Center for Minority Health and Health Disparities