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The History of Chronic Wasting Disease. Dr. Trent Bollinger, CCWHC One World, One Health Symposium Sept. 29, 2004. Spongiform encephalopathies.

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the history of chronic wasting disease

The History of Chronic Wasting Disease

Dr. Trent Bollinger, CCWHC

One World, One Health Symposium

Sept. 29, 2004

spongiform encephalopathies
Spongiform encephalopathies
  • CWD is classified as a TSEs similar to scrapie, Creutzfeldt-Jakob disease (CJD), kuru, transmissible mink encephalopathy, bovine spongiform encephalopathy (BSE)
slide3

PrPSc

PrPC

Prusiner, S. B. 1999. An introduction to prion biology and diseases.

Pages 1-66 in S. B. Prusiner, editor. Prion Biology and Diseases.

Cold Springs Harbor Laboratory Press, Cold Springs Harbor, New York.

slide5

Two ways in which

spongiform encephalopathies

develop

PrPSc

2) PrPSc transmitted

to new host

+/- Protein X

PrPC

PrPSc

PrPC

PrPSc

PrPSc

  • Spontaneous
  • conversion

PrPSc

PrPC

PrPSc

PrPSc

+/- Protein X

PrPC

PrPSc

+/- Protein X

slide6

PrPSc

PrPSc

PrPc

“ Species barrier”

+

X

Species/Individual A

slow

+

Species/Individual B

fast

+

Species/Individual C

slide7

Sheep Natural Scrapie

13 months

Mice 1st passage

6 m

Mice 2nd passage

4 m

Mice 3rd passage

4.5 m

Mice 4th passage

5 m

Mice 5th passage

PrPSc

moPrPC

+

moPrPSc

moPrPSc

moPrPC

+

moPrPSc

slide8

X

Mule deer -CWD

hamsters

4 -6 m

17 - 21 months

8 m

5 m

Ferrets

CWD

Ferrets

CWD

Types of species susceptible to a prion isolate can

be altered by transmission of prions to other species

Bartz, et al, 1998

methods of transmission
Methods of transmission
  • Direct inoculation
    • Experimental exposure
    • Iatrogenic exposure of humans to CJD
    • Vaccine for louping ill in sheep contaminated with scrapie prion
  • Ingestion
    • Experimental exposure
    • BSE: sheep scrapie to cattle and then cattle to cattle
    • Kuru in humans
    • vCJD in humans
  • Direct animal to animal spread
    • Scrapie in sheep
    • CWD in deer and elk
chronic wasting disease
Chronic wasting disease
  • Disease of mule deer, black-tailed deer, white-tailed deer and elk
history of cwd
History of CWD
  • First recognized as a clinical entity in the late 1960s in captive mule deer and elk in Colorado and Wyoming; confirmed as a TSE in late 1970s
slide14
Estimated overall prevalence in endemic areas of Colorado and Wyoming is 4.9% in mule deer, 2.1 % in white-tailed deer and 0.5% in elk.

Miller et al, 2000