Cryo EM of purified Poxvirus particles. 30 nm-thick surface domain (S)b is noted. Poxviruses. From Principles of Virology , Academic Press 2004. Poxvirus particle is large and complex. 100 nm. Poxviridae. Large family of large, complex viruses Infect vertebrate and invertebrate hosts
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30 nm-thick surface domain (S)b is noted
From Principles of Virology, Academic Press 2004
1. Entry and release of core (mechanism unknown).
2-5. Early mRNA synthesis products release core, cause cell proliferation, and local immune suppression.
6-9. DNA synthesized for packaging and as template for intermediate gene expression – products include transcription specificity factors for late gene expression.
10-18. Transcription and translation of late (structural) protein genes; particles assembled at Golgi; particles released on cell lysis or directly infect adjoining cell.