BIOCHEMISTRY OF LEPTIN. Shalini Jain and Hariom Yadav Animal Biochemistry Division Natioanal Dairy Research Institute Karnal-132001 (Haryana), India. How leptin is discovered. Three theories evolved : Thermo regulation influenced the VMH
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Shalini Jain and Hariom Yadav
Animal Biochemistry Division
Natioanal Dairy Research Institute
Karnal-132001 (Haryana), India
Three theories evolved :
16 KDa protein encoded by ob gene.
mice are homozygous for single gene mutation.
High degree of homology
Primary structure of leptin
Two cysteine residues at the 96 and 146 position Disulphide bridge and kink in the D-helix are a essential for proper folding and receptor binding.
Much more research needs to be done to fully realize the potential of leptin in the body
When the medical community does learn more about leptin’s control & regulation,it will surely have a profound impact on the treatment of obesity , infertility