slide1 n.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
Anti-Coagulants PowerPoint Presentation
Download Presentation
Anti-Coagulants

Loading in 2 Seconds...

play fullscreen
1 / 11

Anti-Coagulants - PowerPoint PPT Presentation


  • 259 Views
  • Uploaded on

Anti-Coagulants. Physical Process of Clotting Chemical Process of Clotting Fibrin formation, extrinsic and intrinsic pathways Anti-coagulants Definition Heparin, Low molecular weight heparins, pentasaccharide Structure, properties, biochemical mechanism Direct Thrombin Inhibitors

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Anti-Coagulants' - Olivia


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
slide1

Anti-Coagulants

  • Physical Process of Clotting
  • Chemical Process of Clotting

Fibrin formation, extrinsic and intrinsic pathways

  • Anti-coagulants

Definition

  • Heparin, Low molecular weight heparins, pentasaccharide

Structure, properties, biochemical mechanism

  • Direct Thrombin Inhibitors
  • Coumarins and 1,3-indanediones

Structure, properties, biochemical mechanism

MEDC 604 Anti-coagulants

slide2

A) Physical Process B) Chemical Process

Wound

Wound

aspirin

antithrombins

platelet activation

factor Xa

fibrinogen

release thrombin release of

of ADP generation thromboxane A2

thrombin prothrombin

fibrin

(monomers)

vitamin K-dependent

g-carboxylation of

Glu residues

Further activation of platelets

ADP

receptor

antagonists

GP IIb-IIIa

receptor

antagonists

fibrin

(polymer)

Platelet aggregation

coumarins

CLOT

The Clotting Process

Taken from Desai UR (2004) Med. Res. Rev. 24, 151-181.

MEDC 604 Anti-coagulants

slide3

Chemical Process of Clotting

MEDC 604 Anti-coagulants

slide4

Heparin and Low molecular weight heparins

Structure and sequence

MEDC 604 Anti-coagulants

slide5

Pentasaccharide

MEDC 604 Anti-coagulants

slide6

AT + H

AT:H

AT-E + H

E

Biochemical Mechanism of Heparin Action

MEDC 604 Anti-coagulants

slide7

Heparin can induce clots!!

MEDC 604 Anti-coagulants

slide8

AT

M

AT

AT

AT

Adapted from Hirsh et al. (2001) Chest 119, 64S-94S

Problems with Heparin therapy

proteins

H

EC

  • Heparin-induced thrombocytopenia …. 3.5% of treated patients
  • Heparin resistance …. 25% of VTE patients
  • Unable to inhibit factor Xa in prothrombinase complex
  • Unable to inhibit thrombin bound to fibrin
  • Binds to von Willebrand factor …. Inhibition of platelet function
  • Binds to platelets …. inhibit platelet aggregation
  • Binds to endothelial cells …. Heparin-induced bleeding
  • Inhibits proliferation of vascular SMC
  • Activates osteoclasts to promote bone loss
  • Causes release of TFPI …. Added anticoagulant activity

MEDC 604 Anti-coagulants

slide9

Coumarins and 1,3-indanediones

MEDC 604 Anti-coagulants

slide11

Biochemical Mechanism of Action

MEDC 604 Anti-coagulants