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Incidence. In USA - 400 to 800 deaths/yearParenterally administered penicillin accounts for 100 to 500 deaths per yearHymenoptera stings account for 40 to 100 deaths per yearRisk factors: beta-blockers, adrenal insufficiency. Causes of Deaths. Laryngeal edema and acute bronchospasm with respiratory failure account for >70%Circulatory collapse accounts for 25%Other <5% - ?brain ?MI.

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