Principles of Bioorganic Medicinal Chemistry Drugs & Medicinal Chemist . Lovastatin-Mevacor. August 26/2002. Zbigniew J. Witczak, Ph.D. Principles of Bioorganic & Medicinal Chemistry PHA 598A: Dr. Zbigniew J. Witczak. Learning Objectives
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Drugs & Medicinal Chemist
Zbigniew J. Witczak, Ph.D.
1. Describe the mechanism by which cell macromolecules mediates the cellular response.
2. Identify the cell components and active macromolecules that are involved in the development and regulation of the cellular processes and drug action/response.
3. Identify the pharmacological responses by which the therapeutic agents acts in the multiple cellular system.
4. Identify the chemical aspects of drug action and their pharmacological responses.
Therapeutic Index ******
( the lethal dose for 50 % of the test animals) to the ED50 ( the effective
dose that produces the maximum therapeutic effect in 50 % of the test animals.