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Human Infertility problem Cassey Lynn Jenaia Delk Josh Heise Eric Rooker Summary The problem: There is an unknown cause of female infertility. Attempted for year to become pregnant Long interval between menstruation Suspect problem w/ ovulation Goals: Stimulate ovulation with drugs

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human infertility problem

Human Infertility problem

Cassey Lynn

Jenaia Delk

Josh Heise

Eric Rooker

summary
Summary
  • The problem: There is an unknown cause of female infertility.
    • Attempted for year to become pregnant
    • Long interval between menstruation
    • Suspect problem w/ ovulation
  • Goals: Stimulate ovulation with drugs
  • Drugs:
    • clomiphene citrate
      • For women w/ infrequent cycles and long cycles
treatment regimen
Treatment Regimen
  • Begin between 2nd-5th day of menses
  • Patient to take 1 or 2 tablets (50-100mg) every day for 5 consecutive days
  • Can induce menstrual cycle w/ progesterone injections or progestin tablets.
  • Pregnancy test before inducing
drug action
Drug Action
  • Name: Clomid, Serophene (Clomiphene Citrate)
  • Target Cells: Estrogen receptors in the hypothalamus
  • Cellular Response: Anti-hormone, competitive inhibition
  • Effect: Block estrogen receptors in hypothalamus to cause increased release of GnRH, LH, and FSH, leading to increased estrogen and ultimately ovulation.
effect of reproductive state
Effect of reproductive state
  • Effective:
    • Early in cycle (2-5 days of menstration)
    • Can induce period (progesterone)
  • Not Effective:
    • Times other than above
    • Women who cannot cycle
    • pregnant
determining effectiveness
Determining effectiveness
  • Cervical mucus test (Billing’s method)
  • Abdominal pain
  • Basal Body Temperature (increase)
  • Blood Tests
  • Ultrasound
  • Ovulation Prediction Kit
  • Endometrial Biopsy
labor input
Labor Input
  • Low input compared to other treatments
  • Cost is roughly $50/ month
    • 2 pills early in cycle
  • Input by medical professional
    • Determine effectiveness and timing of fertilization
    • Doctor visits, AI meetings, ultrasounds
sources
Sources
  • http://www.babycenter.com/0_fertility-treatment-your-options-at-a-glance_1228997.bc
  • http://www.ansci.wisc.edu/jjp1/ansci_repro/lab/lab7/lab7_2003/human_ov_drugs.pdf
  • http://www.ansci.wisc.edu/jjp1/ansci_repro/lab/lab7/lab7_2003/ovuldetect.pdf