Lupus Awareness Ad Council Campaign. Frances E. Ashe-Goins RN, MPHActing Director U.S. DHHS Office on Women\'s HealthWashington, DC. Overview of Lupus . Definition. Lupus is a widespread chronic autoimmune diseaseCauses the immune system to attack the body\'s own tissue and organsThese include the joints, kidneys, heart, lungs, brain, blood and/or skinThe immune system loses its ability to tell the difference between itself and foreign tissue.