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Now it never hurts to look a little younger. ™

Now it never hurts to look a little younger. ™. coatings & inks textile chemicals lubricants agricultural specialties . fatty acids fatty alcohols glycerine bulk surfactants . natural-source vitamin E specialty surfactants emollients & emulsifiers actives .

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Now it never hurts to look a little younger. ™

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  1. Now it never hurts to look a little younger.™

  2. coatings & inks • textile chemicals • lubricants • agricultural specialties • ... • fatty acids • fatty alcohols • glycerine • bulk surfactants • ... • natural-source vitamin E • specialty surfactants • emollients & emulsifiers • actives • ...

  3. Actives from Care Chemicals Generol® Phytosterols Hydagen® Chitosan Innovative Actives Next-generation AHA Technology Advanced Delivery Systems

  4. Dr. Van Scott and Dr. Yu NeoStrata’s headquarters in Princeton, NJ. NeoStrata Company, Inc. Drs. Van Scott and Yu published first paper on skin benefits of AHAs in 1974. Inventors of amphoteric hydroxy complexes for low-irritation AHA actives. NeoStrata holds over 100 patents on AHA technology. Strategic Alliance with Cognis announced in 1999.

  5. Known Benefits of AHAs • Exfoliation • Moisturization • Reduction of fine lines and wrinkles • Collagen synthesis • Firming • Skin whitening Downside: stinging, irritation, ...

  6. the benefits of AHAs with significantly reduced sting and irritation.

  7. Amphoteric Hydroxy Complex

  8. Model of Controlled Release Concept

  9. Dansyl Chloride Cell Turnover Study (10% lactic acid solution vs 14.7% AHCare™ L 65 solution)* pH = 2.4 34% increase in cell renewal rate * the lactic acid concentration is identical in these two solutions

  10. Results for Facial Sting StudyAHC (high arginine) vs. 20% Lactic/NH4OH, neutralized to pH 3.5

  11. Results for Facial Sting StudyAHC (low arginine) vs. 10% Lactic/NH4OH, neutralized to pH 2.2

  12. Results for Facial Sting StudyAHC (high arginine) vs. 10% Glycolic/NH4OH, neutralized to pH 3.1

  13. Results for Facial Sting StudyAHC (low arginine) vs. 10% Glycolic/NH4OH, neutralized to pH 2.3

  14. Cumulative Irritation Study 20% Glycolic Acid Solutions, pH 3.5

  15. AHCare™ is Patented Technology Key patents: • R. J. Yu and E. J. Van Scott, “Amphoteric composition and polymeric forms of alpha hydroxy acids and their therapeutic use,” US Patent 5,091,171 (1992). • R. J. Yu and E. J. Van Scott, “Molecular complex and control-release of hydroxy acids,” US Patent 5,681,853 (1997). • plus 10 others, issued or pending. Cognis has exclusively licensed these patents to commercialize AHCare™ technology based on glycolic and/or lactic acid.

  16. AHCare™ Products Two standard products: • AHCare™ G 60: patented complex of glycolic acid and L-arginine, 74% total actives, glycolic/arginine mole ratio = 15:1 • AHCare™ L 65: patented complex of lactic acid and L-arginine, 75% total actives, lactic/arginine mole ratio = 20:1

  17. Value Proposition for Skin Care Customers When you buy AHCare™ skin care ingredients from Care Chemicals you get: • high efficacy with significantly reduced stinging and irritation • freedom to practice under NeoStrata patents referenced above on a worldwide basis. • formulation support - including frame formula development to match a market target • claims substantiation support - including assistance with test methods for both in vitro and in vivo methods.

  18. Dansyl Chloride Cell Turnover Study Anti-aging Cream containing 10% AHCare™ G 60 21% increase in cell renewal rate

  19. Summary • High efficacy • Significantly reduced stinging and irritation • Freedom to practice under NeoStrata patents • Extensive support

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