1 / 29

Sustained Release | Enteric Coated | Instant Release

We are one of the fastest emerging companies and the biggest manufacturer and exporter of Pellets, Beadlets, Granules, Spheres for Pharmaceutical and Nutraceutical Industries in India.

Labultima
Download Presentation

Sustained Release | Enteric Coated | Instant Release

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Umang Encapsulation Solutions- www.vitaminpremix.com

  2. FOOD & & FOOD NUTRACEUTICAL NUTRACEUTICAL UMANG’S SEGMENT UMANG PHARMATECH UMANG PHARMATECH ENGINEERING ENGINEERING PHARMACEUTICAL PHARMACEUTICAL PERSONAL CARE PERSONAL CARE 2/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  3. Presentation outline Company overview Product range SR Amino spheres Vita spheres Mine spheres Caroten spheres Herbal beadlets Active/enzyem/probiotic beadlets Beadlet & particle technology Benefits & applications Manufacturing & production Method development The path to commercialization Defination & concept of encapsulation SR SR Technologies Conclusion Why umang’s beadlets Floating pellets pH sensitive system EC pellets SR pellets MUPS (multiple unit pellet system) Modified release Taste masking technology 3/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  4. UMANG PHARMATECH PVT.LTD COMPANY OVERVIEW & MISSION Umang Pharmatech has pioneered sustain-release, clean label beadlet technologies for the global nutraceutical and pharmaceutical markets. With a clear mission to develop creative micro encapsulated solutions for a multiplicity of niche and high- demand actives and deliver them as fine, spherical-shaped beadlets. 4/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  5. MANAGEMENT TEAM MR.UMANG R. BUDHRAJA DIRECTOR MR. RAJKUMAR BUDHRAJA MD & CEO 5/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  6. OUR TEAM MR. S.M. SUBHANI R&D & Pharma Production Manager MR. SOURAV MOIRA IT Manager MRS. SUJA MATHEW Finance Manager MR. P. P. VARGHESE Engineering Head MS. KOMAL KAMBLE Quality Assurance Manager MR. SURESH Engineering Production Manager Mr. RAJENDRA PRABHU KELUSKAR QMS Manager MR. KESKAR QC Manager MR. PRASANNA KUMAR Personal Care Manager MR. ALI ASGAR GOLWALA Assistant Sales Manager - (Engineering) MR. SAGAR DAVLEKAR Digital marketing - Assistant Manager 6/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  7. Beadlet & particle technology Beadlet & particle technology • Our nutraceutical beadlets are gaining tremendous interest and garnering health-conscious consumer attention for their many benefits. 1.Company overview and mission 2.Beadlet and particle technology 3.Benefits and application 4.Manufacturing and production 5.Method and development 6.Path to commercialization 7.Defination and concept 8.Technology 9.Product Range 10.Conclusion • As dietary supplement brands demand innovative dosage and delivery systems, we aim to address this paradigm shift from the traditional capsule & tablet to a modern, sophisticated approach to product development. • UPPL is a 38-year old facility in the Mumbai dedicated solely to particle and beadlet technologies. Encapsulation of essential oil in bioplymer beads • Servicing various industries including nutraceutical, personal care, food pharmaceutical Lyophilisate without (up) and with coating (down) 7/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  8. Benefit and application of beadlets Benefit and application of beadlets • Flavor coating and flavor masking of unpleasant tasting ingredients 1.Company overview and mission 2.Beadlet and particle technology 3.Benefits and application 4.Manufacturing and production 5.Method and development 6.Path to commercialization 7.Defination and concept 8.Technology 9.Product Range 10.Conclusion Flexible release points with targeted dissolution in optimal digestive tract location • Greatly reduces active ingredient dose dumping • Free-flowing particles are ideal for manufacturers: ease of capsule filling and clean up • Protective outer layer reduces exposure to oxygen, light, temperature, pH, and other environmental factors, while increasing shelf life • 8/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  9. - Manufacturing and production Manufacturing and production Our Customizable Machinery 1.Company overview and mission 2.Beadlet and particle technology 3.Benefits and application 4.Manufacturing and production 5.Method and development 6.Path to commercialization 7.Defination and concept 8.Technology 9.Product Range 10.Conclusion Extrusion, Spheronizer, Coating, Fluid Bed, Hot Melt, Layering, Cold Water Dispersion, Spary Drying • • • • • • • Facility-10,000 + SF Capacity -300+ MT/mo Expansive & dynamic technical knowledge 38+ years expertise in beadlet manufacturing 200+ employee work force Fully customizable machine parts 9/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  10. Method development Method development Most popular product Method for Single Ingredient And Multi Ingredient Beadlets Iron 1.Company overview and mission 2.Beadlet and particle technology 3.Benefits and application 4.Manufacturing & production 5.Method and development 6.Path to commercialization 7.Defination and concept 8.Technology 9.Product Range 10.Conclusion • Developed for commercialized formulations. Caffeine In-house methodologies are developed utilizing lab testing equipment such as GC, HPLC, etc. Involves ensuring stability of multiple actives. • Vitamin c Capsicum extract • Melatonin Identifying potential interactions of the actives. • Another purpose of method development is to allow for consistent and verifiable 3rd party lab testing. • Drug Master File (DMF) including method development, quality documentation, manufacturing process, and stability work. • Curcumin Lutein Ashwagandha 10/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  11. - - Concept of encapsulation Concept of encapsulation Target Delivery 1.Company overview and mission 2.Beadlet and particle technology 3.Benefits and application 4.Manufacturing and production 5.Method and development 6.Path to commercialization 7.Defination and concept 8.Technology 9.Product Range 10.Conclusion Supplementaries to increase energy, improving mental focus, muscle growth, immune system, bone health etc,are the targets for the delivery of active compounds. • • Level Of Incorporate Active Will depend upon the nature of the active ingredients being encapsulated - - Encapsulated Minerals • • Encapsulated Vitamins 11/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  12. The path to commercialization The path to commercialization - - From Pilot to Full Scale Production 1.Company overview and mission 2.Beadlet and particle technology 3.Benefits and application 4.Manufacturing and production 5.Method and development 6.Path to commercialization 7.Defination and concept 8.Technology 9.Product Range 10.Conclusion Extrusion, Spheronizer, Coating, Fluid Bed, Hot Melt, Layering, Cold Water Dispersion, Spary Drying • • R&D pilot batches are taken at the 550 kg run size to determine if success criteria can be achieved. A range of feasibility concerns are addressed such as release points, appropriate excipients, coloration, particle size, and ultimately the machinery utilized for production scale. • • Once the pilot has been successfully completed and tested for actives and any other goals undertaken are assessed, costs for commercial production are determined. 12/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  13. Defination of encapsulation Defination of encapsulation Encapsulation technology essentially deals with the incorporation of commercially available active material into protective system that can deliver the active to specific site. 1.Company overview and mission 2.Beadlet and particle technology 3.Benefits and application 4.Manufacturing and production 5.Method and development 6.Path to commercialization 7.Defination and concept 8.Technology 9.Product Range 10.Conclusion The core is covered by solid shell which is used to deliver, protect stabilize or control the release of the core/active Protective Shell Usually selected from a list of materials “generally regarded as safe”(GRAS) to meet the needs of the application as well as regulatory demands eg. Biodegradability - • USP Grade Suitable for personal care use • • Core Ingredients encapsulated includes colours, fragrances, flavors, vitamins & oils etc. - • 13/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  14. Technology Technology (control release technology) (control release technology) 1.Company overview and mission 2.Beadlet and particle technology 3.Benefits and application 4.Manufacturing and production 5.Method and development 6.Path to commercialization 7.Defination and concept 8.Technologies -Floating pellets -pH sensitive system -EC pellets -SR pellets -MUPS -Modified release -Taste masking 9.Product Range 10.Conclusion Floating pellets • • The Floating pellets rapidly float in a solution, when it comes into contact with water. A condition for floating pellets is that the active ingredient must have a immediate, sustained or enteric coated properties in water or medium to allow rapid dissolution before administration. There is also a possibility of taste adjustment for bitter molecules. The floating pellets may be manufactured using various technology for vitamins and nutritional applications. • • • • For many years now UMANG has experience in various forms and technology for pelletization of various actives and applications which is advantageous in terms of costs and gives a aesthetic and functional appeal to the customers end product. This manufacturing process led our company to be one of the most performant in this field. 14/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  15. Technology Technology (control release technology) (control release technology) pH sensitive system 1.Company overview and mission 2.Beadlet and particle technology 3.Benefits and application 4.Manufacturing and production 5.Method and development 6.Path to commercialization 7.Defination and concept 8.Technologies -Floating pellets -pH sensitive system -EC pellets -SR pellets -MUPS -Modified release -Taste masking 9.Product Range 10.Conclusion - Controlled drug delivery systems, which are intended to deliver drugs at pre determined rates for pre defend periods of time, have been used to overcome the shortcomings of conventional drug formulations. In this case the drug has to be delivered in response to pH in body. they release protons in response to pH change. pH - Independent formulation - The granules are designed for the oral controlled release of basic or acidic drugs at a rate that is independent of the pH in the GI tract. They are prepared by mixing a basic or acidic drug with one or more buffering agents, granulating with appropriate pharmaceutical excipients, and finally, coating with a gastrointestinal fluid permeable film-forming polymer. When the GI fluid permeates through the membrane, the buffering agents adjust the fluid inside to a suitable constant pH, thereby rendering a constant rate of drug release. 15/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  16. Technology Technology (control release technology) (control release technology) 1.Company overview and mission 2.Beadlet and particle technology 3.Benefits and application 4.Manufacturing and production 5.Method and development 6.Path to commercialization 7.Defination and concept 8.Technologies -Floating pellets -pH sensitive system -EC pellets -SR pellets -MUPS -Modified release -Taste masking 9.Product Range 10.Conclusion EC Pellets (enteric coated pellets/beadlets) Enteric coatings have long been used to inhibit release of drug from tablets and pellets. • • • • Enteric coated dosage forms are designed to resist the acidic environment of the stomach and disintegrate in the higher pH environment of the intestinal fluid. • • To prevent degradation of the drug by gastric contents (Omeprazole, Pancreatin, Esomeprazole etc.) • • • • An Enteric coating protects the drug during transit through the acidic medium of the stomach. Upon entering the higher pH environment of the duodenum, the coating is dissolved and the drug becomes available for absorption. To release the drugs with site-specific absorption in the intestine, to deliver the drugs intended for local action in intestine (intestinal antiseptics) and to provide a lag time of between 3 and 4 hr and to bypass systemic absorption of drugs. • • • • • • 16/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  17. Technology Technology (control release technology) (control release technology) 1.Company overview and mission 2.Beadlet and particle technology 3.Benefits and application 4.Manufacturing and production 5.Method and development 6.Path to commercialization 7.Defination and concept 8.Technologies -Floating pellets -pH sensitive system -EC pellets -SR pellets -MUPS -Modified release -Taste masking 9.Product Range 10.Conclusion MUPS (multiple unit pellet system) It is an approach that has come into existence which combines the features of both controlled release tablets and modified release capsules in one dosage form, such a system is known as MUPS tablets or Multiple-Unit Pellet System • • The Multiple-Unit Pellet System (MUPS) tablets are a kind of multiparticulate system that has become an important and successful dosage form for immediate or modified drug release. These Multiple Units are composed of tablets containing un coated or coated pellets allowing modified drug release. 17/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  18. Technology Technology (control release technology) (control release technology) 1.Company overview and mission 2.Beadlet and particle technology 3.Benefits and application 4.Manufacturing and production 5.Method and development 6.Path to commercialization 7.Defination and concept 8.Technologies -Floating pellets -pH sensitive system -EC pellets -SR pellets -MUPS -Modified release -Taste masking 9.Product Range 10.Conclusion SR Pellets (sustained release pellets/beadlets) Sustained Released Pellets are designed to release a drug in the body slowly over an extended period of time. The basic goal of therapy is to achieve steady state blood level that is therapeutically effective and non toxic for an extended period of time. • • The basic objective in dosage form design is to optimize the delivery of medication to achieve the control of therapeutic effect in the face of uncertain Fluctuation in the vivo environment in which drug release take place. • This is usually concerned with maximum drug availability by attempting to attain a maximum rate and extent of drug absorption however, control of drug action through formulation also implies controlling bio availability to reduce drug • 18/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  19. Technology Technology (control release technology) (control release technology) Modified -release Modified-release use to describe dosage forms having drug release features based on time, course, and /or location which are designed to accomplish therapeutic or convenience objectives not offered by conventional or immediate-release forms. 1.Company overview and mission 2.Beadlet and particle technology 3.Benefits and application 4.Manufacturing and production 5.Method and development 6.Path to commercialization 7.Defination and concept 8.Technologies -Floating pellets -pH sensitive system -EC pellets -SR pellets -MUPS -Modified release -Taste masking 9.Product Range 10.Conclusion Extended-Release - Extended-release products are designed to release their medication in a controlled manner, at a predetermined rate, duration and location to achieve and maintain optimum therapeutic blood levels of drug. 19/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  20. Product range Product range 1.Company overview and mission 2.Beadlet and particle technology 3.Benefits and application 4.Manufacturing and production 5.Method and development 6.Path to commercialization 7.Defination and concept 8.Technologies 9.Product range -Amino spheres SR -Vita spheres SR -Mine spheres -Caroten spheres -Herbal beadlet -Active/enzyems/probiotics beadlet 10.Conclusion SR AMINO SPHERES (Amino acid spheres) SR Ÿ AMINO SPHERES -TR (L-Tryptophan 50%) SR Ÿ AMINO SPHERES -VA (L-Valine 40%) SR Ÿ AMINO SPHERES -PH (L-Phenylalanine 30%) SR SR Ÿ AMINO SPHERES -HI (L-Histidine 50%) SR Ÿ AMINO SPHERES -GL (L-Glutamine 45%) SR Ÿ AMINO SPHERES -ME (DL-Methionine 55%) SR Ÿ AMINO SPHERES -LU (L-Leucine 55%) SR Ÿ AMINO SPHERES -AL (L-Arginine 40%) SR Ÿ AMINO SPHERES -IS (Isolucine) SR Ÿ AMINO SPHERES -TH (L-Threonine Beadlets) SR Ÿ AMINO SPHERES -BR (Branched Chain Amino Acid Beadlets) 20/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  21. Technology Technology (control release technology) (control release technology) 1.Company overview and mission 2.Beadlet and particle technology 3.Benefits and application 4.Manufacturing and production 5.Method and development 6.Path to commercialization 7.Defination and concept 8.Technologies -Floating pellets -pH sensitive system -EC pellets -SR pellets -MUPS -Modified release -Taste masking 9.Product Range 10.Conclusion Taste masking technology • Taste-masking techniques often go hand in hand with the formulation technology. In short, they need to be mutually compatible. For example, coated particles obtained after Fluid-bed coating should be able to withstand the tablet compression process used for the final dosage form (tablet) manufacturing. • The commonly used industrial techniques/methods of taste- masking include organoleptic methods, polymer coating, hot-melt extrusion, micro encapsulation, complexation, and spray-drying. 21/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  22. Product range Product range 1.Company overview and mission 2.Beadlet and particle technology 3.Benefits and application 4.Manufacturing and production 5.Method and development 6.Path to commercialization 7.Defination and concept 8.Technologies 9.Product range -Amino spheres SR SR VITA SPHERES (Vitamin spheres) SR Ÿ VITA SPHERES -A (Vitamin A Beadlets 50%) SR Ÿ VITA SPHERES -D3 (Vitamin D3 Beadlets 0.5%,1%) -Vita spheres -Mine spheres -Caroten spheres -Herbal spheres -Active/enzyems/probiotics beadlet 10.Conclusion SR Ÿ VITA SPHERES -E (Vitamin E Beadlets 40%) SR SR SR Ÿ VITA SPHERES -C (Vitamin C Beadlets 70%,90%) SR Ÿ VITA SPHERES -B1 (Vitamin B1 Beadlets 20% ) SR Ÿ VITA SPHERES -B2 (Vitamin B2 Beadlets 10%) SR Ÿ VITA SPHERES -B3 (Vitamin B3 Beadlets 30%,50%) SR Ÿ VITA SPHERES -B5 (Vitamin B5 Beadlets 40%) SR Ÿ VITA SPHERES -B6 (Vitamin B6 Beadlets 10%, 20%) SR Ÿ VITA SPHERES -B7 (Vitamin B7 Beadlets 20%) SR Ÿ VITA SPHERES -B9 (Vitamin B9 Beadlets 2%, 3%,5%) SR Ÿ VITA SPHERES -B12 (Vitamin B12 Beadlets 3%) 22/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  23. Product range Product range 1.Company overview and mission 2.Beadlet and particle technology 3.Benefits and application 4.Manufacturing and production 5.Method and development 6.Path to commercialization 7.Defination and concept 8.Technologies 9.Product range -Amino spheres -Vita spheres -Mine spheres -Caroten spheres -Herbal spheres -Active/enzyems/probiotics beadlet 10.Conclusion SR MINE SPHERES (Mineral spheres) SR Ÿ MINE SPHERES -CS (Copper Sulphate Beadlets 1%) SR Ÿ MINE SPHERES -KL (Potassium Chloride Beadlets 90%) SR Ÿ MINE SPHERES -FA (Ferrous Ascorbate Beadlets 65%) SR SR SR Ÿ MINE SPHERES -SE (Selenium Beadlets 1%) SR SR Ÿ MINE SPHERES -DS (Dried ferrous sulphate 65%) SR Ÿ MINE SPHERES -IO (Iodine Beadlets 0.5%) SR Ÿ MINE SPHERES -BO (Boron Beadlets 2%) SR Ÿ MINE SPHERES -ZN (Zinc Beadlets 60%) SR Ÿ MINE SPHERES -CA (Calcium Beadlets 75%) SR Ÿ MINE SPHERES -FS (Ferrous Sulphate Beadlets 65%) SR Ÿ MINE SPHERES -FC (Carbonyl Iron Beadlets 60%) SR Ÿ MINE SPHERES -FO (Ferrous Fumarate Beadlets 65%) SR Ÿ MINE SPHERES -MG (Magnesium Beadlets 85%) 23/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  24. Product range Product range 1.Company overview and mission 2.Beadlet and particle technology 3.Benefits and application 4.Manufacturing and production 5.Method and development 6.Path to commercialization 7.Defination and concept 8.Technologies 9.Product range -Amino spheres -Vita spheres -Mine spheres -Caroten spheres -Herbal spheres -Active/enzyems/probiotics beadlet 10.Conclusion CAROTEN SPHERES (carotenoid spheres) Ÿ CAROTEN SPHERES -LU 10x (Lutein Beadlets 10%) Ÿ CAROTEN SPHERES -CQ 10x (CoQ10 Beadlets 10%) Ÿ CAROTEN SPHERES -LU 20x (Lutein Beadlets 20%) Ÿ CAROTEN SPHERES -BC 10x (Beta-Carotene Beadlets 10%) Ÿ CAROTEN SPHERES -LU 25x (Lutein Beadlets 25%) Ÿ CAROTEN SPHERES -BC 20x (Beta-Carotene Beadlets 20%) SR SR Ÿ CAROTEN SPHERES -LY 5x (Lycopene Beadlets 5%) Ÿ CAROTEN SPHERES -MX 10x (Mixed Carotene Beadlets 10%) SR Ÿ CAROTEN SPHERES -LY 10x (Lycopene Beadlets 10%) Ÿ CAROTEN SPHERES -MX 15x (Mixed Carotene Beadlets 15%) Ÿ CAROTEN SPHERES -LY 20x (Lycopene Beadlets 20%) Ÿ CAROTEN SPHERES -ZN 2x (Zeanthanin Beadlets 2%) Ÿ CAROTEN SPHERES -ZN 5x (Zeaxanthin Beadlets 5%) Ÿ CAROTEN SPHERES -ZN 10x (Zeaxanthin Beadlets 10%) Ÿ CAROTEN SPHERES -AN 2.5x (Astaxanthin Beadlets 2.5%) Ÿ CAROTEN SPHERES -AN 3x (Astaxanthin Beadlets 3%) Ÿ CAROTEN SPHERES -AN 5x (Astaxanthin Beadlets 5%) Ÿ CAROTEN SPHERES -CQ 5x (CoQ10 Beadlets 5 %) 24/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  25. Product range Product range 1.Company overview and mission 2.Beadlet and particle technology 3.Benefits and application 4.Manufacturing and production 5.Method and development 6.Path to commercialization 7.Defination and concept 8.Technologies 9.Product range -Amino spheres -Vita spheres -Mine spheres -Caroten spheres -Herbal spheres -Active/enzyems/probiotics beadlet 10.Conclusion HERBAL SPHERES SR SR Ÿ ASHWA SPHERES -0.6X (Ashwagandha Beadlets 0.6%) Ÿ BRAMHI SPHERES -40X (Bramhi Beadlets 40%) EC Ÿ CURCUMA SPHERES -90X (Curcuma Longa 90%) SR Ÿ CALENDULA SPHERES -40X (Calendula Beadlets 40%) EC Ÿ CAPSICUM SPHERES -0.1X (Capsicum Beadlets 0.1%) SR Ÿ AMLA SPHERES -40X (Amla Beadlets 40%) SR SR SR Ÿ BOSEWA SPHERES -85X (Bosewellia Serrata Beadlets 85%) SR EC Ÿ FENUK SPHERES -50X (Fenugreek Beadlets 50%) EC Ÿ GARLIC SPHERES -1X (Garlic Beadlets 1%) EC Ÿ SAFFRAN SPHERES -2X (Saffron Beadlets 2%) EC Ÿ GINGER SPHERES -25X (Ginger Beadlets 25%) EC Ÿ ECHINICHEA SPHERES -4X (Echinichea Beadlets 4%) EC Ÿ CRANB SPHERES -25X (Cranberry Beadlets 25%) 25/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  26. 26/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  27. Conclusion Conclusion 1.Company overview and mission 2.Beadlet and particle technology 3.Benefits and application 4.Manufacturing and production 5.Method and development 6.Path to commercialization 7.Defination and concept 8.Technologies 9.Product range 10.Conclusion Why umang’s beads • These beads can be manufactured in any size and color of your size • The edge of these beads are smooth to avoid microscopic tears on skin surface • Uses a unique manufacturing process that creates the spherical beads 27/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  28. CERTIFICATIONS CERTIFICATIONS 28/30 Umang Encapsulation Solutions- www.vitaminpremix.com

  29. GLOBAL PRESENCE GLOBAL PRESENCE Umang Encapsulation Solutions- www.vitaminpremix.com UMANG PHARMATECH Survey no 146 H. No.1(PT), Vasai Phata Highway Junction, NH8,Pelhar,Vasai (E) 401208 29/30

More Related