opiate receptor pharmacology l.
Skip this Video
Loading SlideShow in 5 Seconds..
Opiate Receptor Pharmacology PowerPoint Presentation
Download Presentation
Opiate Receptor Pharmacology

Loading in 2 Seconds...

play fullscreen
1 / 9

Opiate Receptor Pharmacology - PowerPoint PPT Presentation

  • Uploaded on

Opiate Receptor Pharmacology. Donald R. Wesson, MD. Opiate Receptors and effect of Agonist. Schematic of Mu Opiate Receptor. Source: Goodman and Gillman 9 th ed, p. 526. Agonist Partial Agonist Antagonists. Morphine-like effect (e.g., heroin, weak binding except for Fentanyl)

I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
Download Presentation

PowerPoint Slideshow about 'Opiate Receptor Pharmacology' - KeelyKia

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.

- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
opiate receptor pharmacology

Opiate Receptor Pharmacology

Donald R. Wesson, MD

schematic of mu opiate receptor
Schematic of Mu Opiate Receptor

Source: Goodman and Gillman 9th ed, p. 526

receptor binding at mu receptor

Partial Agonist


Morphine-like effect (e.g., heroin, weak binding except for Fentanyl)

Weak morphine-like effects with strong receptor affinity (e.g., buprenorphine)

No effect in absence of an opiate or opiate dependence (e.g., naltrexone)

Receptor Binding at Mu receptor
effect of common opiates at mu receptor
Heroin, morphine, methadone





Partial Agonist


Effect of Common Opiates at Mu Receptor
buprenorphine pharmacology
Buprenorphine Pharmacology
  • Partial agonist at mu receptor
  • High affinity for mu receptor
  • Can displace full opiate agonist such as heroin or methadone
    • Displacement of heroin or methadone by buprenorphine can produce opiate withdrawal symptoms
buprenorphine pharmacology8
Buprenorphine Pharmacology
  • Antagonist at kappa receptor
  • Poor bio-availability taken orally (extensive first pass metabolism)
  • Much more bio-available from sublingual mucosa (Peak 2-3 hours following sublingual dose)