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Lipid Metabolism - PowerPoint PPT Presentation


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Lipid Metabolism. Lipid Metabolism. Lipid Metabolism. Lipid Metabolism. Digestion - Hydrolysis Reaction. Lipid Metabolism. Lipid Metabolism. Fatty Acid Oxidation. Initial Step: Requires an ATP to synthesize acetyl CoA with the fatty acid. Beta Oxidation. Beta Oxidation. Beta Oxidation.

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Presentation Transcript
lipid metabolism4
Lipid Metabolism
  • Digestion - Hydrolysis Reaction
fatty acid oxidation
Fatty Acid Oxidation
  • Initial Step: Requires an ATP to synthesize acetyl CoA with the fatty acid.
palmitic acid atp synthesis
Palmitic Acid -ATP Synthesis
  • Palmitic Acid is C-16
  • Initiating Step - requires 1 ATP (text says 2)
  • Step 1 - FAD into e.t.c. = 2 ATP
  • Step 3 - NAD+ into e.t.c. = 3 ATP
  • Total ATP per turn of spiral = 5 ATP
  • Example with Palmitic Acid = 16 carbons = 8 acetyl groups
  • Number of turns of fatty acid spiral = 8-1 = 7 turns
  • ATP from fatty acid spiral = 7 turns and 5 per turn = 35 ATP.
  • NET ATP from Fatty Acid Spiral = 35 - 1 = 34 ATP
palmitic acid c 16 atp synthesis
Palmitic Acid (C-16) -ATP Synthesis
  • NET ATP - Fatty Acid Spiral = 35 - 1 = 34 ATP
  • Review ATP - Citric Acid Cycle start with Acetyl CoA
  • Step ATP produced
  • 7 visible ATP 1
  • Step 4 (NAD+ to E.T.C.) 3
  • Step 6 (NAD+ to E.T.C.)   3
  • Step10 (NAD+ to E.T.C.)  3
  • Step 8 (FAD to E.T.C.) 2
  •  NET12 ATP per turn C.A.C.
  • 8 Acetyl CoA = 8 turns C.A.C.
  • 8 turns x 12 ATP/C.A.C. = 96 ATP
  • GRAND TOTAL130 ATP