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Lipid Metabolism. Digestion & absorption . Introduction Fat is a good source of energy as 1 gm supplies 9.1 calories, which is over double that supplied by carbohydrates or protein. Dietary lipids are ingested in form of

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lipid metabolism

Lipid Metabolism

Digestion & absorption

slide2

Introduction

  • Fat is a good source of energy as 1 gm

supplies 9.1 calories, which is over double

that supplied by carbohydrates or protein.

  • Dietary lipidsare ingested in form of

triglycerides,phosholipids,cholesterol and free fatty acids.

  • A minimal amount of fat is essential in our food to provide an adequate supply of the essential fatty acids.
slide3

Lipids are esters of fatty acids with various alcohols:

R-COOH + R-OH RCOOR + H2O

Fatty acid + Alcohol Ester + Water

  • Fatsareesters of fatty acids with glycerol called triglycerides because they are tri-esters of glycerol
fatty acids
Fatty acids

These are carboxylic acids

their general formula R- COOH.

fatty acids are classified into

  • saturated
  • unsaturated fatty acids

according to absence or presence of double bonds.

1 saturated fatty acids
1- Saturated fatty acids
  • Saturated chain fatty acids are based on acetic acid CH3-COOH.
  • no double bonds

CH3 - COOH is acetic acid,

CH3 – CH2 – COOHis propionic acid

CH3 – CH2 – CH2 – COOH butyric acid and so on.

2 unsaturated fatty acids
2- Unsaturated fatty acids

They have one or more double bonds.

biological importance of lipids
Biological Importance Of Lipids:

1- Energy production, dietary lipids supply the body with about 25% of calories needed every day.

2- They provide the body with

  • Essential fatty acid
  • Fat soluble vitamins
  • Phosphours in the form of phospholipids
slide8

Fats under the skin are used as insulater protecting the body against external temp.

  • Combinations of fat and protein (lipoproteins) are important cellular constituents and serve for the transport of lipids in the blood.
  • Cholestrol is used for synthesis of adrenal cortical hormones, vitamin D3 and bile acids.
digestion of lipids
Digestion of lipids

1- Digestion of triglycerides:

  • Ingested triglycerides first are emulsified and then undergo enzymatic hydrolysis by lipase enzymes.

1- Emulsification:

  • Breakdown of large fat globule into small ones
  • done in the mouth by chewing.
  • in the stomach by peristaltic contractions.
  • in intestine by peristaltic movement, bile salts.
slide11

2- Digestive fat enzymes:

  • Are lingual lipase, gastric lipase, pancreatic lipaseandintestinal lipase.
  • The most active is pancreatic lipase.

1-Lingual lipase: Is secreted by the dorsal surface of the tongue (Ebner's glands),

but this enzyme is not of much significance in humans as compared with rat or mouse.

slide12

2-Gastric lipase (pH 3-6):

In the stomach some digestion occurs by gastric lipase

hydrolyzing triglycerides containing short, medium and unsaturated long chain fatty acids

to form FFA and 1,2 diglycerides

slide14

3-Pancreatic lipase:

  • Bile salts

assist emulsification by lowering surface tension

exposing large area of triglycerides

pancreatic lipase will dissolve fatty acids.

slide15

Pancreatic lipase

acts on finely emulsified lipid droplets

in presence of

1- bile salts.

2- colipase (a protein present in pancreatic

secretion).

3- phospholipase A2 (Ca++ is necessary for

phospholipase A2 activity).

slide16

Pancreatic lipase hydrolyses the primary ester bond with the production of 2FFA + β-monoglyceride.

  • Hydrolysis of monoglyceride requires transfer of the FA from beta to alpha carbons of glycerol by specific isomerase enzyme.

this process is very slow. So the major digestion products of TGareβ-monoglyceride and FA.

slide18

4-Intestinal lipase:

Act within intestinal mucosal cells where it may hydrolyse primary monoglyceride

glycerol and FFA.

2 digestion of phospholipids
2-Digestion of phospholipids:
  • Glycerophospholipids are hydrolyzed by pancreatic enzyme phospholipase A2

which remove FA in position 2 to form lysophospholipids.

slide20

Intestinal phospholipase

may complete the hydrolysis of lysophospholipids

glycerol + FA + phosphoric acid

slide21

3-Digestion of cholesterol esters:

Cholesterol ester are hydrolyzed by cholesterol ester hydrolase (cholesterol esterase) into FA and free cholesterol

absorption of lipids
Absorptionof lipids
  • The end products of lipid digestion are: FA – glycerol - monoglyceride - cholesterol and lysophospholipid.

1- Short(less than 10 carbon atoms) and medium chain fatty acids (10-12C) together with free glycerol are water soluble

  • absorbed to the intestinal cell by diffusion and passes directly to the liver through the portal circulating.
slide23

2- monoacylglycerol +long chain fatty acids + cholesterol and lysophosphoatide

are absorbed through the plasma membrane of the intestinal cells (jejunum and ileum) together withbile salts

forming soluble complexes with them(Micelles).

inside the intestinal cells
Inside the intestinal cells:
  • bile salts are separated and carried out to the liver via the portal circulation and then secreted with the bile in the intestine.

This known as enterohepatic circulation of bile salts.

inside the intestinal cells1
Inside the intestinal cells:
  • long chain fatty acids are activated by thiokinase enzyme(acyl COA synthetase) forming acyl COA.
slide28

T.G are formed also from free glycerol in intestinal cells from dihydroxyacetone phosphate (from glycolysis).

Activated by glycerokinase enzyme

slide29

Resynthesis of phospholipids & cholesterol esters by combination of cholesterol and lysophospholipids absorbed with acyl-CoA.

  • The triglycerides, phospholipids & cholesterol ester and cholesterol bind with

a protein (apolipoprotein B48) to formchylomicrons

which enter lacteals and pass with lymphatic drainage to the thoracic duct to reach systemic circulation.

fate of absorbed lipid
Fate of absorbed lipid
  • Immediately after absorption of lipids there is turbidity of plasma due to the circulating chylomicrons (appear in plasma 2 hours after meals).
  • This turbidity is soon cleared by lipoprotein lipase enzyme (clearing factor).
  • This enzyme hydrolyses triglycerides of

chylomicrons to glycerol and FFA.

  • Glycerol is transported to liver to be metabolized

as carbohydrate.

slide32

Free fatty acids are carried by plasma albumin to adipose tissues liver and other tissues for metabolism.

  • MOST dietary fat transported to adipose for storage