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Sickle Cell Anemia. PathophysiologyGenetic abnormality causes red cells to contain hemoglobin S rather than hemoblobin AAt low oxygen tensions hemoglobin S forms long, rigid rodsRBCs become distorted, sickle-shaped. Sickle Cell Anemia. PathophysiologySickled RBCs cannot pass through small vesselsThrombosisInfarctionSickled RBCs are fragileHemolysis.

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