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CRITICAL PERIOD. Modified from MacLusky and Naftolin Science 1981; 211:1294 - 1303. OH. Testosterone. O. Aromatase. 5 a - Reductase. OH. HO. O. Estradiol. 5 a - DHT. Androgen-dependent sexual dimorphism in the CNS. Ultrastructural differences Neuronal nuclear and nucleolar size

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critical period
CRITICAL PERIOD

Modified from MacLusky and Naftolin Science 1981; 211:1294 - 1303

slide2
OH

Testosterone

O

Aromatase

5a - Reductase

OH

HO

O

Estradiol

5a - DHT

androgen dependent sexual dimorphism in the cns
Androgen-dependent sexual dimorphism in the CNS
  • Ultrastructural differences
    • Neuronal nuclear and nucleolar size
  • Differences in synaptic or dendritic organization
  • Differences in the gross volume of defined cell groups
slide6
CELL MIGRATION

A

B

Arnold and Gorski 1984

slide7
10 20 30 12 36 60 Age (weeks) Time (hr)
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