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IMPLICATIONS OF RESEARCH FINDINGS FOR PROGRAMS TO REDUCE MICRONUTRIENT DEFICIENCIES. December 10, 2003. PLEASE TAKE NOTE. The “FINDINGS” cited in the following slides summarize results reported in the literature
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December 10, 2003
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Source: Presentation by Ruth Harvey at IVACG, February 2003. (Complete paper will appear on MOST web site shortly.)
Source: Clive E. West and Ans Eilander, Bioefficacy of carotenoids in the Sight and Life Newsletter, Feb 2000.
Source: Rahman AS, et. al. Randomized, Double-blind Controlled Trial of Wheat Flour (Chapatti) Fortified with Vitamin A and Iron in Improving Vitamin A and Iron status in Healthy, School Aged Children in Rural Bangladesh. Report submitted to MOST, May 2003
Source: West, KP et al. Double blind, cluster randomised trial of low dose supplementation with vitamin A or beta carotene on mortality related to pregnancy in Nepal. BMJ. 1999 Feb 27;318(7183):570-5.
Sources: 1Rahmathullah L, et al. Impact of supplementing newborn infants with vitamin A on early infant mortality: community based randomised trial in southern India. BMJ. 2003 Aug 2;327(7409):254. 2Humphrey JH, et al. Impact of neonatal vitamin A supplementation on infant morbidity and mortality. J Pediatr. 1996 Apr;128(4):489-96.
Sources: 1Lozoff B, et al. Behavioral and developmental effects of preventing iron-deficiency anemia in healthy full-term infants. Pediatr. 2003 Oct;112(4):846-54. 2Algarin C, et al. Iron deficiency anemia in infancy: long-lasting effects on auditory and visual system functioning. Pediatr Res. 2003 Feb;53(2):217-23. 3Stoltzfus RJ, et al. Effects of iron supplementation and anthelmintic treatment on motor and language development of preschool children in Zanzibar: double blind, placebo controlled study. BMJ. 2001 Dec 15;323(7326):1389-93. 4Idjradinata P, Pollitt E. Reversal of developmental delays in iron-deficient anaemic infants treated with iron. Lancet. 1993 Jan 2;341(8836):1-4.
Source: Majumdar I, et al. The effect of iron therapy on the growth of iron-replete and iron-deplete children. J Trop Pediatr. 2003 Apr;49(2):84-8.
Sources: 1Haidar J, et al. Daily versus weekly iron supplementation and prevention of iron deficiency anaemia in lactating women. East Afr Med J. 2003 Jan;80(1):11-6. 2Agarwal KN, et al. Anemia prophylaxis in adolescent school girls by weekly or daily iron-folate supplementation. Indian Pediatr. 2003 Apr;40(4):296-301.
Sources: 1Hernandez M, et al. Iron bioavailability and utilization in rats are lower from lime-treated corn flour than from wheat flour when they are fortified with different sources of iron. J Nutr. 2003 Jan;133(1):154-9. 2Swain JH, et al. Bioavailability of elemental iron powders to rats is less than bakery-grade ferrous sulfate and predicted by iron solubility and particle surface area. J Nutr. 2003 Nov;133(11):3546-52. 3Alvarado M, De Leon LF, Dary O. Technical and economical evaluation of wheat flour fortification with different iron compounds. Nutrition Institute of Central America and Panama (INCAP), unpublished report.
Sources: SUSTAIN Guidelines for Iron Fortification of Cereal Food Staples.
Sources: Source: Olivares M, et al. Prevention of iron deficiency by milk fortification. The Chilean experience. Acta Paediatr Scand Suppl. 1989;361:109-13.
Sources: Chavasit V, et al. Combating iodine and iron deficiencies through the double fortification of fish sauce, mixed fish sauce, and salt brine. Food Nutr Bull. 2003 Jun;24(2):200-7. Thuy PV, et al. Regular consumption of NaFeEDTA-fortified fish sauce improves iron status and reduces the prevalence of anemia in anemic Vietnamese women. Am J Clin Nutr. 2003 Aug;78(2):284-90.
Sources: 1Zlotkin S, et al. Treatment of anemia with micrencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods. Am J Clin Nutr 2001; 74: 791-5. 2Zlotkin S, et al. Home-fortification with iron and zinc sprinkles or iron sprinkles alone successfully treats anemia in infants and young children. J Nutr. 2003 Apr;133(4):1075-80.
Sources: 1Green NS. Folic acid supplementation and prevention of birth defects. J Nutr. 2002 Aug;132(8 Suppl):2356S-2360S. 2Castilla EE, et al. Preliminary data on changes in neural tube defect prevalence rates after folic acid fortification in South America. Am J Med Genet. 2003 Dec 1;123A(2):123-8.
© US Agricultural Research Service
Source: 1Noh SK and Koo SI. Low zinc intake decreases the lymphatic output of retinol in rats infused intraduodenally with beta-carotene. J Nutr Biochem. 2003 Mar;14(3):147-53. 2Munoz EC et al. Iron and zinc supplementation improves indicators of vitamin A status of Mexican preschoolers. Am J Clin Nutr. 2000 Mar;71(3):789-94.
Sources: 1Bhutta ZA, et al. Prevention of diarrhea and pneumonia by zinc supplementation in children in developing countries: pooled analysis of randomized controlled trials. J Pediatr. 1999 Dec;135(6):689-97. 2Bhandari N, et al. Effect of routine zinc supplementation on pneumonia in children aged 6 months to 3 years: randomised controlled trial in an urban slum. BMJ. 2002 Jun 8;324(7350):1358.
Source: Brown KH, et al. Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2002 Jun;75(6):1062-71.
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