From The Friengs To The Forefront mRAN is here to Transform Global Health

1. A market research report on From the Fringes to the Forefront: mRNA is here to Transform Global Health

2. mRNA: The Understanding Discovered in 1960, mRNA stands for “messenger ribonucleic acid” or “messenger RNA”; basically the mRNA is software of life Advantages of mRNA: • Speed of design and scalability of manufacturing mRNA over other vaccines and therapies has a very major advantage DNA mRNA Protein • Another advantage that mRNA may offer over other more traditional vaccine types (such as live attenuated vaccines, inactivated vaccines and sub-unit vaccines) and over DNA based vaccines is safety Software Application Storage mRNA is a temporary set of instructions for cells to make a protein Proteins form the basis of life by performing the function required by every cell • mRNA is non-infectious and non-integrating (i.e. it does not cause DNA insertions) which gives it a further advantage over attenuated and DNA based vaccines DNA stores instructions for proteins in the nucleus 2

3. mRNA Becomes the Rising Star of Nucleic Acid Therapy How does the mRNA works? 1 4 2 3 Cellular machinery follows the mRNA instructions to produce viral proteins mRNA provides genetic instructions to make viral proteins Viral proteins induce an immune response Antibodies are ready to combat viral infection • After decades of research and the accumulation of theoretical knowledge, the COVID-19 pandemic in early 2020 brought mRNA to the forefront as a new modality, and finally reached the tipping point in demonstrating its utility in infectious diseases • mRNA vaccines, upon delivery, tell our cells to synthetize proteins, e.g., resembling those from the coronavirus (the SARS-Cov-2 spike proteins) • This cellular generation of proteins then elicits an immune response in which the body produces virus-neutralizing antibodies even before infection with the real pathogen 3

4. mRNA made Headlines in 2020 Moderna is a leader in mRNA technology mRNA made headlines in December 2020 when one of the world’s first COVID-19 vaccines, developed by US-based pharmaceutical company Moderna, the National Institute of Allergy and Infectious Diseases (NIAID), and the Biomedical Advanced Research and Development Authority (BARDA), began rolling out to members of the public Moderna’s vaccine was developed at unprecedented speed, and its public launch marked a turning point in the pandemic. By the end of last year, the company had shipped more than 800 million vaccines worldwide, with approximately 25 percent shipped to low-to-middle income countries through direct sales or donations The Company’s mRNA platform is intrinsically flexible, allowing the company to move mRNA medicines quickly from idea to development candidate nomination. This means it can be used to contain future COVID outbreaks and manage yearly mutations, staying ahead of the virus’ evolution The company’s manufacturing platform was designed so that it would not need to amend production processes to produce new boosters or mRNA vaccines 4

5. mRNA Therapies: Clinical Pipeline Assets Line Items Split by Therapeutic Areas Line Item Split by Clinical Phase 44 Assets 40 Unique Products 15 Companies 5

6. Who should buy this report? HealthTech MedTech Other Lifesciences Pharmaceutical Digital Health Companies Players Companies Players Entities

7. Topics of Upcoming Reports Will the Expiry of Humira Market Exclusivity and Entry of its Biosimilars Move the Needle in BioPharma Market? From the Fringes to the Forefront: mRNA is here to Transform Global Health Cost of this report: Melting the Iron Triangle: 10 Healthcare Players aiming Beyond Health Equality to Conquer Health Equity $2,500 Robotics: Embarking a New Era in Surgical Innovations Annual Subscription: Metaverse: Paving the way for Health 4.0 Healthcare Future Outlook 2023 $125,000 $60,000 Patient Engagement- a New Standpoint on Care that is Patient-Centered (Includes a total of 50 reports) E-Rx, the Digital Version of Prescription Improvising the Chances of Better Patient Outcomes www.insights10.com Integration of Healthcare Systems with Big Data and Data Silos

8. Methodology & Scope

9. Research Methodology Insights 10’s research methodology delves deeper into the market, covering the macro and micro aspects of the industry. We identify the key growth drivers, opportunities, and restraints that might promote or hinder the future industry growth along with an expansive overview of the competitive landscape to help our clients make informed strategic decisions ▪ ▪ We implement a mix of primary and secondary research for our market estimate and forecast. The secondary research forms the initial phase of our study where we conduct extensive data mining, referring to verified data sources such as independent studies, government and regulatory published material, technical journals, trade magazines, and paid data sources ▪ For forecasting, the following parameters are considered: ❑ Market drivers and restraints along with their current and expected impacts ❑ Technological scenario and expected developments ❑ End use industry trends and dynamics ❑ Trends in the consumer behavior ❑ Regulatory scenario and expected developments ❑ Current capacity and expected capacity additions up to 2030 ▪ We assign weights to these parameters and quantify their market impacts using the weighted average analysis to derive the expected market growth rate ▪ We appoint data triangulation strategies to explore different areas of the market. Our qualitative and quantitative assessments are time-sensitive, reflecting the most recent value and volume of the market across regions ▪ ▪ All our estimates and forecasts are verified through exhaustive primary research with the Key Industry Participants (KIPs) Currency used in the report is the US dollar (USD), with the market size indicated in USD million/billion (Mn/Bn) 9

10. Analysis Methodology Our Analysis Methodology involves three critical stages: Market Data Analysis & Statistical Model Interpretation & Presentation Data Collection Analysis & 01 01 Market Trends Interpretation Secondary 01 Research Market Sizing & Insights 02 02 Analysis Primary 02 Research Presentation & Data Triangulation & 03 03 Reporting Validation 10

11. Data Triangulation & Data Validation Top Down Approach Final Market Size Final Market size break up to rest of segmentation Bottom Up Approach Top Down Approach Validation from Primary Interview Arriving at market size of each segment Summarization of revenue generated from companies to arrive at total market size Validation from Primary Interview Revenue generated by products & services offered by companies Final Summary Bottom Up Approach 11

12. Key Benefits for Stakeholders from this Report Study provides an in-depth analysis of the market with current trends and future estimations to elucidate the imminent investment pockets Our tools provides stakeholders with a cohesive understanding of the industry outlook, considering the qualitative and quantitative industry variables Comprehensive analysis of factors that drive and restrict the market growth is provided Comprehensive quantitative analysis of the industry from 2021 to 2030F is provided to enable the stakeholders to capitalize on the prevailing market opportunities Extensive analysis of the key segments of the industry helps understand the applications and technologies used globally Our rigorous data collection, thorough statistical analysis and specialist assessments ensure that our clientele has a greater understanding of the industry space, supply chain, price fluctuations, competitive landscape, and other vital factors 12

13. Time Frame Report Attribute Details Quantitative Units Revenue in USD Million/Billion (Mn/Bn) Base Year for 2021 Market Overview, Revenue Forecast, Market Segmentation, Growth Factors and Trends, Company Profiles, Competitive Landscape, Regulatory Landscape, Future Opportunities Estimation Report Coverage Report Customization (5 working days) with purchase. We will provide you with data that is currently not a part of our scope as a part of customization Customized Report Forecast 2022- 2030 Period Pricing and purchase Avail customized purchase options to meet your exact research needs options

14. What kind of Data is Presented in this Report? This report presents data, which is: Reliable Expert-verified Real Comprehensive Easy to read The data is prepared by Covers everything you You do not have to be a Allowing you to The report is prepared a team of highly qualified would need to know market expert to confidently make using a proven & experienced research about the market understand what really is smarter business methodology and analysts & vetted by our including market size, happening on the market and strategic insightful research local associates competitive analysis & and how it works decisions much more www.insights10.com

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16. Lifesciences Market Research Reports you can trust A large database of over 30,000 syndicated market research reports in pharmaceuticals and healthcare sector at global, regional as well as country level. We also provide customized research reports tailor made to suit your needs www.insights10.com

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22. Over the years, we have developed an in-depth experience of executing market analysis at global, regional & country specific level in life sciences. Our team has conducted market research across 62+ global markets in America, Europe, Middle East, Africa and Asia Pacific regions Research Projects Done

23. Project Leadership Team Dr. Purav Gandhi Founder & CEO Mukesh Nayak Head - Marketing Ritu Baliya Engagement Manager Dhruv Joshi Consultant Purav is a physician and an Mukesh is an engineering graduate Ritu has over 6 years of experience in Dhruv Joshi is an engineer and has done entrepreneur with 12+ years of with an MBA in Marketing. He is a strategy building, market assessments, Masters in Hospital Administration with experience in Healthcare & Life seasoned healthcare market market sizing, and RWE for global MNC over 4 years of experience in the Sciences industry spanning across research & marketing professional healthcare & biopharma clients across healthcare and life science industry. He strategy, market access, health with a progressive experience of over diff. markets (America, Europe, Africa, has gained proficiency in market informatics and RWE, Digital 20 years in Life Sciences, Pharma APAC and Middle East). Her areas of research, market assessment, and Healthcare, analytics and data science. and Medical Device sectors . With an expertise include: Indentifying emerging developing insights from it. He has Purav studied medicine from Gujarat in-depth understanding of primary trends in life sciences industry, worked on various consulting projects University and also completed his MBA research, he has conducted Competitor landscape assessment, across different geographies including from IIM-Kozhikode. Purav started his hundreds of interviews of various Disease opportunity assessments etc. Asia, Europe, US, MENA. He has been career with Deloitte working on strategy stakeholders in pharma & healthcare She is a pro in secondary and primary aligned in working for sector reports of consulting engagements and also & completed several research research with a deep domain expertise various geographies along with market co-founded ConvergeHealth by projects across life sciences industry. in healthcare sector. sizing and forecasting. Deloitte.

24. 7 years of experience working with leading organizations in pharma, MedTech and healthcare domain. Some of our recent clients are mentioned below … and many more

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