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Dr Christianne Bruschke Scientific and Technical Department. «  Poultry HPAI Vaccination: Decision Making ». GDLN seminar Paris, 19 March 2008. Documents on HPAI Vaccination. OIE Code Chapter 2.7.12: Avian Influenza OIE Terrestrial Manual:

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Dr Christianne Bruschke

Scientific and Technical Department

« Poultry HPAI Vaccination: Decision Making »

GDLN seminar

Paris, 19 March 2008

documents on hpai vaccination
Documents on HPAI Vaccination

OIE Code

  • Chapter 2.7.12: Avian Influenza

OIE Terrestrial Manual:

  • Chapter I.1.7: Principles of Vet. Vaccine Production
  • Chapter 2.1.14: Highly Pathogenic Avian Influenza

In Collaboration with FAO:

  • OIE information document on avian influenza vaccination (March 2006)
  • OIE guidelines on vaccination against HPAI (May 2007)
guidelines on the implementation of ai vaccination
Guidelines on the implementation of AI Vaccination

To guide countries in their decision making on

the implementation of eradication strategies including vaccination

To establish detailed guidelines and a checklist for the application, monitoring, precautionary measures of vaccination strategies

strategy from beginning to minimize threat at animal source
Strategy from Beginning:To Minimize Threat at Animal Source
  • Early detection and early warning
  • Rapid and transparent notification
  • Rapid confirmation of suspects
  • Rapid response
    • use of vaccination when available and if appropriate
vaccination
Vaccination
  • Induction of immune response
    • Protection against morbidity, mortality and decline of egg production
  • Higher resistance to infection
  • Decrease of virus shedding
  • Reduction of spread between birds and flocks

Vaccination should always be complemented by other measures like increase biosecurity, movement controls and stamping out

analysis before vaccination decision
Analysis before Vaccination decision
  • National regulations
  • Local epidemiological situation
  • Zoo-technical aspects
  • Socio-economic aspects
  • Capacity of the Veterinary Services
  • Financial situation
  • Availability of sufficient high quality vaccine
  • Trade implications
local epidemiological situation
Local epidemiological situation
  • Knowledge of the outcome surveillance system
  • Status neighboring countries
  • Status trade partners
  • Presence of legal or illegal international trade
  • Presence of live bird markets
  • Infection status wild birds
  • Human health implications
zoo technical aspects
Zoo -technical aspects
  • Poultry production systems in place (sectors 1-4)
  • Poultry species reared
  • Multi age system
  • Biosecurity levels
  • Sources of feed and water
  • Poultry workers and husbandry practices
socio economic factors
Socio-Economic Factors
  • Culture
  • Public Acceptance
  • Compensation schedules
  • Food security aspects
  • Small holders livelihoods
  • Financial aspects of eradication
vaccination strategy
Vaccination Strategy
  • Emergency in the face of an epidemic
  • Preventive when high risk of incursion and insufficient response measures
  • Routine in an endemic situation
  • Mass vaccination: all susceptible poultry are vaccinated
  • Targeted vaccination: defined categories of birds are vaccinated
vaccine strain
Vaccine strain

Choice of the vaccine strain

  • Homologous or Heterologous
  • Monovalent or Bivalent
  • Recombinant

Vaccine production according to OIE standards to assure high quality

principles of veterinary vaccine production
Principles of Veterinary Vaccine Production
  • Quality Assurance
  • Efficacy and Safety tests
  • Stability
  • Batch Control
  • Field tests
  • Production facilities
  • Etc

Specific requirements for HPAI vaccines in chapter on highly pathogenic avian influenza

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World organisation for animal health

12 rue de Prony

75017 Paris, France

Tel: 33 (0)1 44 15 18 88

Fax: 33 (0)1 42 67 09 87

Email: oie@oie.int

http://www.oie.int