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General Principles of Transmembrane Signaling. Binding of antigen leads to clustering of antigen receptors on lymphocytesClustering of antigen receptors leads to activation of intracellular signal moleculesPhosphorylation of receptor cytoplasmic tails by tyrosine kinases concentratesintracellular signaling molecules around the receptorsintracellular signaling components recruited to activated receptors transmitthe signal onward from the membrane and amplify it.

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Dimerization and Autophosphorylation of Receptor Protein-Tyrosine Kinases


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